National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
This study evaluated the Phytochemical profile and antibacterial potential of Senna montana fruits (Pods) extracts against four clinically significant human pathogens. Utilizing a systematic solvent -polarity gradient (Aqueous, Ethanolic, Ethyl acetate and n-Hexane), the investigation revealed diverse array of pharmacologically active therapeutic secondary metabolites within the ethanolic extract yielding the highest concentration of Phenols, tanins, flavonoids. Antibacterial assays against a panel of Human pathogens (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae) demonstrated significant, dose-dependent growth inhibition. The ethanolic extract exhibited superior efficacy, producing Zones of Inhibition (ZOI) of 21.0–23.5 mm at 100 mg/mL. Notably, biostatistical benchmarking via Two-way ANOVA and Tukey’s HSD confirmed that the antimicrobial potency of the ethanolic extract is statistically comparable to clinical standards. These findings suggest that Senna montana pods serve a profilic reservoir bioaccessible secondary metabolites and as a significant lead for the isolation of bioactive molecules in the pursuit of novel antimicrobial drug discovery.
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