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Original Research Articles                      Volume : 15, Issue:2, February, 2026

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2026.15(2): 41-52
DOI: https://doi.org/10.20546/ijcmas.2026.1502.004


Synthesis of Silicon Dioxide Nanoparticle as Biologically Derived Therapeutic Agent using Streptomyces hygroscopius and Leafy Extracts of Cynodon dactylon
Sona Shanmugasundharam1, Nithiyalakshmi Mohanam1, Gopikrishnan Venugopal2 and Ayyasamy Pudukkadu Munusamy1*
1Department of Microbiology, Periyar University, Salem - 636011, India 2Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai - 600119, India
*Corresponding author
Abstract:

Nanotechnology involves the design, production and application of structures, devices and systems by controlling the shape and size at the nanometre scale. It is currently considered as potential technology which brings the many benefits to diverse areas such as drug development, water decontamination, information, production of stronger and lighter material etc. Si NPs are most extensively used in the biomedical field due to their higher stability in pH, temperature and other chemicals which leads to superior biocompatibility, cost-effective and eco-friendly. In the present study we used Streptomyces hygroscopius (microbial approach) and C. dactylon leaf extract (green approach) as comparative for the synthesis of silicon dioxide nanoparticles. The actinobacterial strain was identified as Streptomyces hygroscopius (RGS17) with accession number MZ031397. The biosynthesized SiO? nanoparticles were confirmed through UV-Vis spectroscopy with characteristic absorbance at 320 nm and XRD analysis indicated their amorphous nature. FTIR analysis revealed the presence of various functional groups contributing to the reduction, capping and stabilization of the nanoparticles. SEM analysis confirmed the spherical morphology of both Sh-SiNPs and C. dactylon-mediated SiNPs. The antibacterial activity tests showed that Sh-SiNPs had stronger inhibitory effects against Escherichia coli and Bacillus cereus, suggesting encouraging medicinal potential. the efficiency of actinobacterium-mediated silica nanoparticle manufacturing as a bioactive and sustainable method for antibacterial and antioxidant applications.


Keywords: Silicon dioxide, C. dactylon, Anti-oxidant, Anti-bacterial activity, Streptomyces hygroscopius mediated silica nanoparticles (Sh-SiNPs)


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How to cite this article:

Sona Shanmugasundharam, Nithiyalakshmi Mohanam, Gopikrishnan Venugopal and Ayyasamy Pudukkadu Munusamy. 2026. Synthesis of Silicon Dioxide Nanoparticle as Biologically Derived Therapeutic Agent using Streptomyces hygroscopius and Leafy Extracts of Cynodon dactylon.Int.J.Curr.Microbiol.App.Sci. 15(2): 41-52. doi: https://doi.org/10.20546/ijcmas.2026.1502.004
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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