National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Injudicious use of antibiotics in hospitalized patients increases the risk of Clostridium dif icile associated diarrhea (CDAD). This study was conducted to determine the incidence of C. difficile as a cause of antibiotic associated diarrhea in pediatric patients in our hospital. Sixty infants and children with a history of antibiotic intake whether having diarrhea or not and 30 age and sex matched patients with no history of antibiotic intake were studied prospectively over a period of one year. Stool samples were processed for C. difficile isolation and examined for C. dif icile toxin A and B by the enzyme-linked immunosorbent assay. 26 out of 60 cases (43.3%) suffered from diarrhea. Only (22/60) showed positive stool culture for C. dif icile, 18 out of them had diarrhea while the remaining 4 patients had no diarrhea and only colonized with toxigenic C. dif icile representing 11.8% of total 34 cases without diarrhea. Toxin A and B were detected in 16 patients including 4 asymptomatic carriers and 12 out of 26 cases with diarrhea representing 46.2%. The incidence of CDAD in our hospital was 46.2%. The asymptomatic carriage rate was 11.8%.
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