National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Today, cognitive disorder is one of the considered issues and many people all over the world are suffering from Alzheimer's disease and other cognitive disorders and dementia. Studies have shown a reduction in the size of the hippocampus in Alzheimer's disease and have suggested that it can be used to evaluate Alzheimer's disease and its progression. The purpose of this study was to investigate the relationship between serum lipids levels and the size of the hippocampus. In an analytical-descriptive study, 41 patients with different clinical symptoms whom referred to take brain magnetic resonance image (MRI) in a center under the direction of Tabriz University of Medical Sciences (Tabriz, Iran) were evaluated. Right and left hippocampal and brain volume was calculated by MRI at coronal T1-weighted. In these patients level of serum low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), and total cholesterol were measured. The mean age of patients was 54.09±3.11 years. 21 patients (51.22%) were male and 20 patients (48.78%) were female. HDL cholesterol level in patients was 51.55±10.23 mg/dl. Mean LDL-C levels in patients was 123.63±47.42 mg/dl. The average volume of the left hippocampus was 1.62±0.39 ml and the average volume of the right hippocampus was 1.61±0.42 ml. There was no significant correlation between serum lipid profile levels with the size of the hippocampus (p>0.05). In present study, there was a weak positive correlation between serum level of HDL-C, TG with right and left hippocampal to brain volume ratio, but the correlation was not statistically significant, and there was a weak negative correlation between serum total cholesterol with right and left hippocampal to brain volume ratio, but the correlation is not statistically significant too.
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