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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(4): 2206-2214
DOI: https://doi.org/10.20546/ijcmas.2017.604.258


Bacteriological Profile and Clinical Outcome in Cases of Neonatal Sepsis
Renuka Anegundi1, Raghavendra D. Kulkarni2, Vidyavathi B. Chitharagi3*, G.S. Ajantha2, C. Shubhada2 and Ami Varaiya4
1Department of Microbiology, Kasturba Medical College, Manipal, Karnataka, India
2Department of Microbiology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India
3Department of Microbiology, JSS Medical College, Mysore, Karnataka, India
4Infection Control Officer, Nanavati Superspeciality Hospital, Mumbai, Maharashtra, India
*Corresponding author
Abstract:

Neonatal septicemia is a clinically diagnosed condition having diverse etiology and changing antibiotic sensitivity pattern. The knowledge of common bacterial agents causing septicemia and their antibiogram is useful in deciding empirical antimicrobial therapy. The neonatal blood cultures were studied to know the bacterial species and their antibiotic sensitivity pattern. Aim of the study is to evaluate sensitivity pattern of bacterial isolates causing neonatal septicemia and to know clinical outcome of the cases. Automated blood cultures of 250 neonates, clinically diagnosed to have septicemia were performed using BacT/ALERT 3D (BioMerieux). Bottles flagging positive were processed for identification and antibiotic susceptibility tests by Kirby Bauer disc diffusion method. Of the 250 cases studied, blood culture was positive in 117 (46.8%). Gram positive organisms were predominant (42.2%), followed by Gram negative organisms (29.7%). CoNS, Klebsiella pneumoniae, Acinetobacter spp., Escherichia coli were commonest organisms isolated accounting for 29.7%, 10.2%, 6.2% and 5.4% of cases respectively. All gram positive isolates were susceptible to vancomycin and linezolid. Most of gram negative isolates were susceptible to imipenem. Mortality rate was 10.4% with 65.4% blood culture positivity. Blood culture helps in rapid and early diagnosis of neonatal sepsis with early shift from empirical therapy to definitive treatment.


Keywords: Blood culture, Gram negative bacilli, Mortality, Neonatal sepsis, Treatment.
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How to cite this article:

Renuka Anegundi, Raghavendra D. Kulkarni, Vidyavathi B. Chitharagi, G.S. Ajantha, C. Shubhada and Ami Varaiya. 2017. Bacteriological Profile and Clinical Outcome in Cases of Neonatal Sepsis.Int.J.Curr.Microbiol.App.Sci. 6(4): 2206-2214. doi: https://doi.org/10.20546/ijcmas.2017.604.258