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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(10): 370-378
DOI: http://dx.doi.org/10.20546/ijcmas.2016.510.042


 Inducible Clindamycin Resistance among Staphylococcus aureus Isolates in Government Medical College, Aurangabad, India
Shaikh Ambreen Fatema Abdul Hafiz*, M.S. Harbade (Duthade), A.A. Gaikwad, A.S. Damle and J.A. Iravane
Department of Microbiology, Government Medical College, Aurangabad, India
*Corresponding author
Abstract:

Staphylococcus aureus is one of the most common human pathogens with ability to cause wide range of infections. The increasing incidence of a variety of infections due to hospital acquired and community associated methicillin-resistant Staphylococcus aureus (MRSA) has led to emphasis for need of safe and effective agents. Clindamycin is commonly used drug for MRSA as it is safe, effective, less costly and can be given orally. Due to extensive use of this antibiotic, it has developed resistance by this mechanism and hence it is important to detect resistance to clindamycin. The Clinical laboratory Standards Institute (CLSI) recommends D test for detecting inducible resistance phenotypically. Aim of the study was to see the Clindamycin resistance pattern in S.aureus (Staphylococcus aureus) isolates. During a period of one year i.e. in 2015,724 S.aureus isolates from various clinical samples were evaluated and methicillin resistance was determined using Cefoxitin (30 mcg) disc and inducible resistance to clindamycin was detected by D-test as per CLSI guidelines (2014). We observed that among 724 S.aureus isolates inducible resistance was found in 124(17.12%); 94 (19.02%) of 494 Methicillin Resistant S.aureus (MRSA) isolates and 30 (13.04%) of 230 Methicillin Sensitive S.aureus (MSSA) isolates showed inducible resistance. Study showed that D test should be used as mandatory method in routine disc diffusion testing to detect inducible Clindamycin resistance for optimum treatment of patients.


Keywords: Clindamycin, MRSA,MSSA, Constitutive MLSB,inducible MLSB
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How to cite this article:

Shaikh Ambreen Fatema Abdul Hafiz, M.S. Harbade (Duthade), A.A. Gaikwad, A.S. Damle and J.A. Iravane. Inducible Clindamycin Resistance among Staphylococcus aureus Isolates in Government Medical College, Aurangabad, India.Int.J.Curr.Microbiol.App.Sci. 5(10): 370-378. doi: http://dx.doi.org/10.20546/ijcmas.2016.510.042