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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(10): 150-155
DOI: http://dx.doi.org/10.20546/ijcmas.2016.510.017


Comparative Evaluation Studies of CSF ADA Activities in Different Neurological Deficit Groups of Patients with Special Emphasis on Meningitis in Indian Scenario
K.Goswami1*, S. Mookherjee2, K. Sridhar3, M. Narayanan3 and P. Pal4
1Department of Biochemistry, Lincoln University College, Kuala Lumpur, Malaysia
2North City Diagnostics, Kolkata, West Bengal, India
3Meril Diagnostics Pvt. Ltd, Vapi, Gujarat, India
4Department of Pharmacology, IIMSAR & Dr. B C Roy Hospital, Haldia, West Bengal, India
*Corresponding author
Abstract:

Tubercular Meningitis (TBM) is an endemic disease in developing countries. Adenosine deaminase activity (ADA) has been of great importance for many years in TBM diagnosis. The present study has been undertaken to assess the levels of CSF-ADA activity in different types of meningitis patients, diagnosed as per clinical and other findings (CSF- Cell Count and Types and.CSF Protein and Sugar content) in comparison to Control group, who are to be considered as other than those with meningitis based on clinical and CSF studies. In total, 98 CSF samples were collected from different groups of patients comprising different types of meningitis (Aseptic, Pyogenic, Tubercular, Fungal and Control groups, consisting of 22 patients in each group excepting Fungal Meningitis group having 10 patients. The control group consisted of 22 people without Meningitis. CSF ADA activity was found to be significantly higher (30 IU/L with a mean of 20.99 + 4.66) in tubercular meningitis in comparison to other groups of meningitis. Other cases & the control group showed ADA concentration of 1.36 + 0.59 IU/L. The present Study also reveals that CSF ADA concentration was found to be < 5 IU/L in control group.


Keywords: CSF,ADA,Tubercular Meningitis (TBM).
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How to cite this article:

Goswami, K., S. Mookherjee, K. Sridhar, M. Narayanan and Pal, P. 2016. Comparative Evaluation Studies of CSF ADA Activities in Different Neurological Deficit Groups of Patients with Special Emphasis on Meningitis in Indian Scenario.Int.J.Curr.Microbiol.App.Sci. 5(10): 150-155. doi: http://dx.doi.org/10.20546/ijcmas.2016.510.017