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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(7): 4008-4023
DOI: https://doi.org/10.20546/ijcmas.2018.707.467


Methanol Leaves Extract of Psidium guajava Linn. Exhibited Antibacterial and Wound Healing Activities
Steve Endeguele Ekom and Jean-De-Dieu Tamokou*
Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
*Corresponding author
Abstract:

The objective of this study was to investigate the antibacterial activity and healing efficacy of Psidium guajava leaf on an excision-wound infected with S. aureus using a rat model. The antibacterial activities of the methanol leaf extract alone and combinations of the plant extract with amoxicillin as well as the effect of osmotic stress were determined by using broth microdilution method. The therapeutic effect of the methanol extract was evaluated on an excision-wound infected with Staphylococcus aureus. The plant extract displayed antibacterial activity (MIC = 256 – 1024 μg/ml) that varied according to the tested bacterial species. Synergistic effect between amoxicillin and P. guajava extract was observed. The antibacterial activity of the plant extract and chloramphenicol increased under osmotic stress condition whereas that of amoxicillin decreased under this condition. P. guajava extract ointments and Baneocin ointment gave the shortest epithelization times and highest wound contraction rates as well as the greatest weights and total protein contents of granulation tissues as compared to the negative control. The P. guajava methanol extract ointment is non-irritating to the skin and slightly irritating to the eyes. The results of the present study demonstrate the wound healing and antibacterial properties of P. guajava and confirm its traditional use in the treatment of wounds and infectious diseases.


Keywords: Psidium guajava; Methanol extract, Antibacterial, Wound healing, Synergy, Osmotic stress, Toxicity
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How to cite this article:

Steve Endeguele Ekom and Jean-De-Dieu Tamokou. 2018. Methanol Leaves Extract of Psidium guajava Linn. Exhibited Antibacterial and Wound Healing Activities.Int.J.Curr.Microbiol.App.Sci. 7(7): 4008-4023. doi: https://doi.org/10.20546/ijcmas.2018.707.467