Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(9): 650-658
DOI: http://dx.doi.org/10.20546/ijcmas.2016.509.075


An Essential Role for TGF-β1 and other Clinical Parameters in Non-alcoholic Fatty Liver Disease in Iraqi Patients
Huda Jaber Waheed1*, Mostafa Abdulfatah Shafek2 and Huda Abdul Ridha Hadi2
1University of Al-Mustansiriyah, College of Pharmacy, Clinical Laboratory,Science Department, Iraq
2Al-Yarmook Teaching Hospital, Baghdad, Iraq  
*Corresponding author
Abstract:

The aim of this study was to explore the potential role of Transforming growth factor-beta1 (TGF-β1), tumor necrosis factor-alpha (TNF-alpha) and serum high-sensitivity C-reactive protein (hs-CRP) in the Non-alcoholic fatty liver disease (NAFLD). A total of (30) patients with Non-alcoholic fatty liver disease (NAFLD) were included in this study. All patients received the concentrations of serum TGF-β1,TNF-alpha and hs-CRP were measured, and compared with (20) healthy subject as control group. Serum TGF--β1 concentration in patients with NAFLD (4.33±0.36 ng/ml) was significantly higher than healthy controls (2.83±0.18 ng/ml), [P < 0.05], as well as, TNF-alpha levels in patients were (42.76±2.54pg/ml) which significantly higher [P < 0.05] than the control group (42.76±2.54 pg/ml).  Serum hs-CRP levels in patients were (4.51±0.87mg/L) and in control group (2.12±0.19mg/L). The area under ROC curve, hs_CRP ~ TNF-α= 0.0656,   hs_CRP ~ TGF-β1= 0.273; TGF-β1 ~ TNF-α= 0.4561). TGF--β1 was the more sensitive than TNF-α and hs-CRP (73.3%, 63.3% and 60.0%, respectively). Serum TGF-β1, TNF-alpha and hs-CRP significantly elevated in patients with NAFLD. TGF-β1 was more sensitive than the other two studied parameters.Serum TGF-β1, TNF-alpha and hs-CRP may be used as a markers for monitor the development of NAFLD and can reflect the severity of liver damage.


Keywords: NAFLD,TGF-β1,TNF-alpha,hs-CRP.
Download this article as Download

How to cite this article:

Huda Jaber Waheed, Mostafa Abdulfatah Shafek and Huda Abdul Ridha Hadi. 2016. An Essential Role for TGF-β1 and other Clinical Parameters in Non-alcoholic Fatty Liver Disease in Iraqi Patients.Int.J.Curr.Microbiol.App.Sci. 5(9): 650-658. doi: http://dx.doi.org/10.20546/ijcmas.2016.509.075