National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Muscle injuries present frequently in sports medicine. Healing with conventional therapy is often inadequate, leading to incomplete functional recovery due to fibrosis. Generating substantial interest in the potential for emerging technologies such as platelet-rich plasma (PRP) to enhance soft-tissue healing and decrease time of recovery became mandatory. The aim of this work was to evaluate the role of PRP in promoting healing of experimentally induced skeletal muscle injury in adult male albino rat model. 48 adult male albino rats were used and were divided into three groups. Group I was served as control for obtaining muscle specimens from their gastrocnemius muscle and PRP. Group II was exposed to bilateral gastrocnemius muscles injury and was left without treatment. Group III were subjected to bilateral gastrocnemius injury and were immediately treated with PRP intramuscularly. Muscle specimens were excised after 1, 7 and 21 days from the onset of injury to be processed for light microscopic study after staining with Mallory trichrome stain. Assessments of the mean area percentage of collagen fibers were also statistically analyzed. Treatment with PRP resulted in enhanced regeneration of skeletal muscle injury without fibrosis. The PRP treated group demonstrated absence of fibrosis on days 14 and 21 as compared to their associates in non-treated group. Local injection of PRP into the injured gastrocnemius muscle resulted in enhanced muscle regeneration without fibrosis.
Citations |
 |
 |
 |
 |
