International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 7, Issue:7, July, 2018

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(7): 3127-3134

Biotransformation of Terfenadine to Fexofenadine by Absidia corymbifera ATCC 14058
Tankeswar Nath*, Manab Bikash Gogoi and Pranab Kumar Nath
DBT-AAU Centre, Assam Agricultural University, Jorhat-785013, India
*Corresponding author

Fexofenadine is an important medicament having significant antihistaminic activity. It is currently being prepared by chemical route which is in numerous stages of development with a yield of less than 10%. In this study, bio-transformation of terfenadine to fexofenadine was investigated using few microbial strains. Among the microbes studied, Absidia corymbifera ATCC14058 showed the highest conversion efficiency in a base line study. Therefore, process conditions conducive to conversion of terfenadine to fexofenadine were optimized using this strain. The growing cell-masses of this strain showed the maximum molar conversion of 99.19% and 94.76% at 200ppm and 500ppm substrate concentration, respectively. Above 500ppm substrate concentration, molar conversion efficiency found to be decreased considerably with increased concentration of substrate. However, the split-dose addition of substrate showed better conversion than the single dose addition. Again, growing cell-catalysts showed the highest substrate conversion over the resting cell-catalysts and cell-free extract. This strain also showed the ability to convert terfenadie to fexofendine in biphasic solvent systems. Among the different biphasic systems, the Ethanol-water and Dimethyl formamide (DMF)-water systems showed reasonably good results. The microbial bioconversion of terfenadine to fexafenadine with biphasic system is a new approach and carries greater promise for further research.

Keywords: Absidia corymbifera ATCC 14058, Terfenadine, Fexofenadine, Biotransformation, Molar conversion

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How to cite this article:

Tankeswar Nath, Manab Bikash Gogoi, Pranab Kumar Nath. 2018. Biotransformation of Terfenadine to Fexofenadine by Absidia corymbifera ATCC 14058Int.J.Curr.Microbiol.App.Sci. 7(7): 3127-3134. doi:
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