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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(7): 2614-2618
DOI: https://doi.org/10.20546/ijcmas.2018.707.306


Pharmacokinetics and Tissue Residue Study of Levofloxacin Following Multiple Dose Intramuscular Administration in Poultry
Preeti Bisht, A.H. Ahmad, Alok Mishra and Sankalp Sharma*
Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, G.B.P.U.A &T. Pantnagar, India
*Corresponding author
Abstract:

The present study was undertaken to investigate the pharmacokinetics and tissue residue study of levofloxacin @ 10.0 mg.kg-1 in poultry (n=16) following multiple (5) dose intramuscular (i.m.) administration. The concentration of levofloxacin in plasma and tissue of these animals were analysed by HPLC. Following multiple dose i.m. administration volume of distribution, clearance, AUC and elimination half-life after first dose was 5925.34 ml.kg-1, 1401.3 ml.h-1.kg-1, 7.32 h.µg.ml-1 and 2.97h, respectively and 5193.88 ml.kg-1, 1663.16 ml.h-1.kg-1, 6.42 h.µg.ml-1 and 2.30h after the last dose. Residue of levofloxacin was present in kidney, liver and muscle upto 72h post administration of levofloxacin with highest concentration of 0.14µg.g-1in kidney. The limit of detection in tissue was 0.02µ.g-1.


Keywords: Levofloxacin, Pharmacokinetics, HPLC, Tissue residues, Poultry
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How to cite this article:

Preeti Bisht, A.H. Ahmad, Alok Mishra and Sankalp Sharma. 2018. Pharmacokinetics and Tissue Residue Study of Levofloxacin Following Multiple Dose Intramuscular Administration in Poultry.Int.J.Curr.Microbiol.App.Sci. 7(7): 2614-2618. doi: https://doi.org/10.20546/ijcmas.2018.707.306