National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
To isolate, identify and detect Carbapenem resistance producing Acinetobacter spp., and confirm Metallo Beta Lactamase ( MBL) production by phenotypic methods. This cross sectional study conducted in a tertiary care hospital for a period of 6 months from various clinical samples were identified using standard protocol. The MBL resistant strains of Acinetobacter species were identified by Kirby-Bauer disc diffusion methods and confirmed by phenotypic methods. Out of clinically significant isolates of Acinetobacter spp., 50 (67%) were Acinetobacter baumannii and 25 (33%) were Acinetobacter lwoffi. The antimicrobial susceptibility pattern revealed maximum resistance to Gentamycin (64%), Cotrimoxazole, Amikacin & Ciprofloxacin (40%) and Cefotaxime and Ceftazidime (36%). Sensitivity to Polymyxin B (100%) followed by Imipenem and Meropenem (90%). Among them 7 (9.3%.) isolates were MBL producers. Among the 7 isolates, CDDT was positive in 5(71%) isolates, DDST was positive in 3(43%) isolates. Acinetobacter baumannii were the most common isolate in this study. Difference in antimicrobial susceptibility poses a great problem in treating these infections. MBL production by these organisms leads to high morbidity and mortality and left with the only option of treating them by potentially toxic drugs like Colistin and Polymyxin B.
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