National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The major histocomtability complex in sheep is also called as Ovar- MHC and is a central molecule for antigen presentation coding for specialized antigen presenting glycoproteins. Studies related to internal parasitic infestations and their association with genetic diversity in MHC region has suggested that some alleles of MHC DRB gene might augment the immune response against parasitic antigens and also may hamper parasitic fecundity inside the host. The exon 2 of DRB 1 gene forms the part of antigen loading clamp of MHC and hence carries the greatest importance in relation to disease resistant research. We sequenced the target exon in four Indian sheep breeds, the sequences were submitted to NCBI. The sequences were then studied using bioinformatic tools to ascertain its structural features and phylogenetic relationship. Finally it was observed that the variation between the sequences is majorly present in intronic region which forms an excellent marker to study the inheritance of adjoining exon also. Variations within the exons were mostly neutral and didn’t reflect in secondary structure as well as there was no change in the ligand binding site.
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