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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(6): 3790-3793
DOI: https://doi.org/10.20546/ijcmas.2018.706.444


Anticlastogenic Effect of Euphorbia hirta using in vivo Rodent Micronucleus Assay
J. Ranjith*, P. Sriram, S. Ramesh, M. Parthiban, D. Sakthivel and Jangyadutta Dash
Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Chennai-600007, Tamil Nadu, India
*Corresponding author
Abstract:

Aqueous extracts of Euphorbia hirta were used to study the anticlastogenic activity by in vivo rodent micronucleus assay. Mice were administrated two doses, 250 mg/kg and 500 mg/kg orally for a period of seven days and at the end of the seventh day, cyclophosphamide (50 m/kg) was given intraperitoneally. Bone marrow sample were analysed for cytotoxicity and micronucleus. Both the doses were not cytotoxic and clastogenic. There was a significant reduction in the micronucleus formation in bone marrow indicating the anticlastogenic activity of E. hirta.


Keywords: Euphorbia hirta, Anticlastogenicity, Micronucleus assay, Mice
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How to cite this article:

Ranjith J., P. Sriram, S. Ramesh, M. Parthiban, D. Sakthivel and Jangyadutta Dash. 2018. Anticlastogenic Effect of Euphorbia hirta using in vivo Rodent Micronucleus Assay.Int.J.Curr.Microbiol.App.Sci. 7(6): 3790-3793. doi: https://doi.org/10.20546/ijcmas.2018.706.444