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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(6): 2568-2577
DOI: https://doi.org/10.20546/ijcmas.2018.706.303


Effect on Haematological and Biochemical Profiles Following Administration of Ketamine Alone and in Combination with Dexmedetomidine or Butorphanol in Atropinized Dogs
Krishna Kumar Verma*, S. K. Tiwari, Rukmani Dewangan and Raju Sharda
Department of Veterinary Surgery and Radiology, College of Veterinary Science and A.H. Anjora Durg (C.G), India
*Corresponding author
Abstract:

The present study was conducted on 18 healthy dogs of either sex weighing between 10-20 kg to evaluate the effects on various haematological and biochemical profile using ketamine alone and in combination with dexmedetomidine or butorphanol in atropinized dogs. The experimental work was divided into three groups K (ketamine), DK (dexmedetomidine-ketamine) and BK (butorphanol-ketamine). Atropine sulphate @ 0.04 mg/ kg intramuscularly was administered 15 minutes prior to treatment in all the groups of animals. Haematological studies revealed non-significant changes in haemoglobin, Packed cell volume, Total erythrocyte count, Total leucocyte count and Differential leucocyte count at various time intervals after different treatments in group K, DK and BK. Serum glucose showed a significant (P<0.01) increase in all the groups initially which returned to base values by 24 hrs. Other biochemical parameters like serum total protein, serum urea nitrogen, creatinine and serum enzyme viz. AST and ALT values showed non-significant changes at various time intervals in all the three groups but was within normal physiological range. There were transient changes in haemato-biochemical profiles which were compensated and returned towards normalcy by 24 hrs in all the three groups. It was concluded that ketamine in combination with dexmedetomidine or butorphanol can be safely used as general anaesthetic in compromised and clinically healthy dogs.


Keywords: Atropine, Butorphanol, Dexmedetomidine, Dog, Ketamine
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How to cite this article:

Krishna Kumar Verma, S. K. Tiwari, Rukmani Dewangan and Raju Sharda. 2018. Effect on Haematological and Biochemical Profiles Following Administration of Ketamine Alone and in Combination with Dexmedetomidine or Butorphanol in Atropinized Dogs.Int.J.Curr.Microbiol.App.Sci. 7(6): 2568-2577. doi: https://doi.org/10.20546/ijcmas.2018.706.303