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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(6): 2344-2351
DOI: https://doi.org/10.20546/ijcmas.2018.706.280


Pharmacokinetics of Marbofloxacin Following Single and Repeated Dose Intravenous Administration in Broiler Chickens
H. B.  Patel*, U. D. Patel , C. M. Modi  and  D. H.  Bhadarka
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh-362001, India
*Corresponding author
Abstract:

Marbofloxacin is a third generation fluorinated quinolone, exclusively used in veterinary medicine. The dosage regimen of drugs can be optimized by their pharmacokinetic studies. Pharmacokinetics of marbofloxacin after repeated intravenous (i.v.) administration was not reported earlier in any veterinary species. Hence, present study was planned to investigate the pharmacokinetics of marbofloxacin following single (5 mg/kg) and repeated dose (5 mg/kg, for 5 days) i.v. administration in broiler chickens. Following i.v. administration of marbofloxacin, the mean values of elimination half-life (t1/2β) (single dose: 5.55 ± 0.67; repeated dose: 5.12 ± 0.25 h), volume of distribution at pseudo equilibrium Vd(area)(single dose:1.49 ± 0.12; repeated dose: 1.37 ± 0.08 L/kg) and area under curve (AUC) (single dose: 26.80 ± 2.08; repeated dose: 27.60 ± 2.57 µg.h/mL) were found in the present study. Significant difference in total body clearance (ClB) and mean residence time (MRT) were not observed after single or repeated dose i.v. administration. The mean ratio of K12 / K21 was significantly (p < 0.01) higher after repeated i.v. administration compare to single dose. The plasma drug concentration greater than 0.10 ± 0.02 and 0.15 ± 0.03 mg/mL (therapeutically effective concentration) were maintained up to 24 h after single and repeated drug administration, respectively. Marbofloxacin following single and repeated dose i.v. administration (5 mg/kg) showed favorable pharmacokinetic profiles in chickens.


Keywords: Marbofloxacin, Pharmacokinetics, Pharmacodynamics, Single and repeated dose,I.V. administration, Broiler chickens,HPLC with UV detector
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How to cite this article:

Patel, H. B.,   U. D. Patel , C. M. Modi  and Bhadarka, D. H. 2018. Pharmacokinetics of Marbofloxacin Following Single and Repeated Dose Intravenous Administration in Broiler Chickens.Int.J.Curr.Microbiol.App.Sci. 7(6): 2344-2351. doi: https://doi.org/10.20546/ijcmas.2018.706.280