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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(6): 1184-1189
DOI: https://doi.org/10.20546/ijcmas.2018.706.140


Antibiogram and Detection of ESBL Production in Klebsiella species Isolated from Various Clinical Samples
Arati Bhurle, Anushka Devnikar*, Suresh Sonth and Shivakumar Solabannavar
Department of Microbiology, S. Nijalingappa Medical College, Bagalkot – 587102, Karnataka, India
*Corresponding author
Abstract:

Klebsiella species belonging to the family Enterobacteriaceae, are known to cause a variety of human infections such as pneumonia, urinary tract infections, septicaemia, soft tissue infections and are an important cause of healthcare associated infections. The emergence of multidrug resistant Klebsiella is a growing problem worldwide. Klebsiella spp. are one of the most common organisms to carry plasmids encoding ESBL enzyme. They are associated with higher rates of treatment failure and death. In this study, we intend to detect the different species of Klebsiella causing infections and analyze their antibiogram including extended spectrum beta lactamase production. A retrospective study was conducted in the department of Microbiology in a tertiary care hospital. Patient samples in which Klebsiella species was isolated were included in the study. Sample processing and isolate identification was done using standard laboratory techniques. Antimicrobial susceptibility testing and ESBL screening was performed by Kirby Bauer’s disc diffusion method as per CLSI guidelines. A total of 210 Klebsiella spp. were isolated. Sputum (35.7%) was the most frequently received specimen and 94.8% isolates were K. pneumonia. Highest sensitivity was seen towards imipenem. Among urinary isolates, norfloxacin was the least effective drug. 68.6% isolates were ESBL producers. There are limited therapeutic options for treatment with multidrug resistant organisms. Hence, it is becoming very important to prevent colonization and infection by implementing and periodically reinforcing appropriate infection control measures.


Keywords: Klebsiella pneumoniae, Klebsiella oxytoca, Extended spectrum beta lactamase, ESBL, antibiogram
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How to cite this article:

Arati Bhurle, Anushka Devnikar, Suresh Sonth and Shivakumar Solabannavar. 2018. Antibiogram and Detection of ESBL Production in Klebsiella species Isolated from Various Clinical Samples.Int.J.Curr.Microbiol.App.Sci. 7(6): 1184-1189. doi: https://doi.org/10.20546/ijcmas.2018.706.140