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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(6): 1079-1085
DOI: https://doi.org/10.20546/ijcmas.2018.706.128


Seroprevalence of Dengue Infection in Patients Suffering from Acute Febrile Illness in a Tertiary Care Centre–Time to Introduce Dengue Vaccine CYD-TDV to Susceptible Population
Nidhi Prasad1, Vidyut Prakash1*, Keshav Kumar Bimal2 and S.K. Shahi2
1Department of Virology, IGIMS, Patna, Bihar, India
2Department of Microbiology, IGIMS, Patna, Bihar, India
*Corresponding author
Abstract:

Dengue, an important vector-borne viral disease and one of the most common causes of acute febrile illness (AFI), is considered as a notable public health problem because it spreads rapidly by the bite of infected mosquito and has high incidence of mortality, morbidity and economical challenges associated with it. Bihar, having a population of 104, 099, 452, average annual rainfall of 1,186 mm and having a breeding place for vector Aedes, is prone to dengue outbreaks. Recently, the first dengue vaccine, Dengvaxia (CYD-TDV) has been introduced. Objective of the study is to determine seroprevalence of dengue infection in patients suffering from AFI, seroprevalence of susceptible population and to ascertain whether it is appropriate time to introduce dengue vaccine CYD-TDV to susceptible population. A retrospective cross sectional observational study, of records of all patients of AFI, whose sera was subjected to simultaneous detection of dengue NS1 antigen, anti- dengue IgM and IgG antibody was done from July 2016 to July 2017 at a tertiary care center in eastern India. Out of 384 samples tested, a total of 38 (9. 9%) samples tested positive for dengue infection and the remaining, i.e. 346/384 (90. 20%) were negative and the patients were considered susceptible to dengue infection. The seroprevalence of dengue was high especially in post-monsoon period. Besides continuing preventive and control measures, authorities should consider introduction of the dengue vaccine CYD-TDV.


Keywords: Acute febrile illness (AFI), Dengue, Dengue vaccine CYD-TDV, Vector borne viral disease
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How to cite this article:

Nidhi Prasad, Vidyut Prakash, Keshav Kumar Bimal and Shahi, S.K. 2018. Seroprevalence of Dengue Infection in Patients Suffering from Acute Febrile Illness in a Tertiary Care Centre–Time to Introduce Dengue Vaccine CYD-TDV to Susceptible Population.Int.J.Curr.Microbiol.App.Sci. 7(6): 1079-1085. doi: https://doi.org/10.20546/ijcmas.2018.706.128