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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(8): 818-824
DOI: http://dx.doi.org/10.20546/ijcmas.2016.508.091


Changes in the Oxidative Stress Biomarkers in Rat Liver Tissue Exposed to Cadmium and Protect with Hibiscus sabdariffa L. (Ro`ssle) Flower Extract
Khaled N. Al-kubaisy, Rania M. Al-Groom* and Adeeb Al- Amoush
Department of Biomedical Sci. Al-Balqa Applied University, Zarqa university Collage-Zarqa-Jordan
*Corresponding author
Abstract:

Cadmium chloride {Cdcl2} is highly toxic chemical agent, it involves production of reactive oxygen species {Ros} and induce oxidative stress mainly attributed to the impairment of antioxidant defense mechanisms in the body. The study was designed to evaluate the possible role of antioxidant of Hibiscus subdariffa L.flower extract {HSSE} in the protection against cdcl2 – induced oxidative stress in rat liver tissue, specially changes in malondialdehyde {MDA} level, and enzymatic and non-enzymatic antioxidant. The following three experimental group were evaluated {1} control, {2} Cdcl2, Cdcl2 + HSSE. Cdcl2 caused significant decrease in reduced Glutahione {GSH} content, catalase {CAT} and superoxide dismutase {SOD} activities, as well as significant increase in malondialdehyde {MDA} level, indicate that cdcl2 induced hepatotoxicity was mediated through oxidative stress.  In contrast, HSE pretreatment significantly improved Cdcl2 – induced biochemical alterations. These result indicated that HSE has a protective action against Cdcl2 hepatotoxicity and suggest that HSE may find clinical application against a variety of toxins and drugs where cellular damage is a consequence of reactive oxygen species.


Keywords: Cdcl2,Hibiscus sabdariffa extract, oxidative stress biomarkers.
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How to cite this article:

Khaled N. Al-kubaisy, Rania M. Al-Groom and Adeeb Al- Amoush. 2016. Changes in the Oxidative Stress Biomarkers in Rat Liver Tissue Exposed to Cadmium and Protect with Hibiscus sabdariffa L. (Ro`ssle) Flower ExtractInt.J.Curr.Microbiol.App.Sci. 5(8): 818-824. doi: http://dx.doi.org/10.20546/ijcmas.2016.508.091