National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Cadmium chloride {Cdcl2} is highly toxic chemical agent, it involves production of reactive oxygen species {Ros} and induce oxidative stress mainly attributed to the impairment of antioxidant defense mechanisms in the body. The study was designed to evaluate the possible role of antioxidant of Hibiscus subdariffa L.flower extract {HSSE} in the protection against cdcl2 – induced oxidative stress in rat liver tissue, specially changes in malondialdehyde {MDA} level, and enzymatic and non-enzymatic antioxidant. The following three experimental group were evaluated {1} control, {2} Cdcl2, Cdcl2 + HSSE. Cdcl2 caused significant decrease in reduced Glutahione {GSH} content, catalase {CAT} and superoxide dismutase {SOD} activities, as well as significant increase in malondialdehyde {MDA} level, indicate that cdcl2 induced hepatotoxicity was mediated through oxidative stress. In contrast, HSE pretreatment significantly improved Cdcl2 – induced biochemical alterations. These result indicated that HSE has a protective action against Cdcl2 hepatotoxicity and suggest that HSE may find clinical application against a variety of toxins and drugs where cellular damage is a consequence of reactive oxygen species.
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