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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(6): 722-733
DOI: https://doi.org/10.20546/ijcmas.2018.706.085


An Evaluation of the Anti-Cancerous Effects of Tinospora cordifolia and Aristolochia bracteolate Using CADD (Computer Aided Drug Discovery) Tools
Cecilia Joseph1*, S. Preetha2, P.L. Sujatha3*, C. Balachandran4 and N. Punniamurthy5
1Department of Clinics
2Department of Veterinary Pharmacology and Toxicology
4Department of Veterinary Pathology, Madras Veterinary College, Chennai-600 007, Tamil Nadu, India
3College of Food and Dairy Technology, Chennai-600 052, Tamil Nadu, India
5VUTRC, Thanjavur, Tamil Nadu, India
*Corresponding author
Abstract:

Cancer is an imminent global disaster and the incidence of cancer is widespread in animals with malignant characters and lesions like human beings. Keeping in view the importance and advantages of combination therapy using herbal based natural EVP products on the tumour cells, an attempt to explore the influence of combined effect of Aristolochia bracteolata and Tinospora cordiflora’ was analyzed using in silico approach. It was found that the combined effect of Aristolochia bracteolate and Tinospora cordiflora have shown to possess significant anti-proliferative and anti- apoptotic properties. The active principles from both the plants possess significant pharmaco kinetic and pharmacodynamics effects. As they work synergistically, the combined effect may be a promising drug entity to enter the evidence based therapeutics for cancer.


Keywords: Cancer, Tinospora cordifolia and Aristolochia bracteolate, in-silico study
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How to cite this article:

Cecilia Joseph, S. Preetha, P.L. Sujatha, C. Balachandran and Punniamurthy, N. 2018. An Evaluation of the Anti-Cancerous Effects of Tinospora cordifolia and Aristolochia bracteolate Using CADD (Computer Aided Drug Discovery) Tools.Int.J.Curr.Microbiol.App.Sci. 7(6): 722-733. doi: https://doi.org/10.20546/ijcmas.2018.706.085