Human Immunodeficiency virus (HIV) with co infection of hepatitis B virus (HBV), Hepatitis C virus (HCV) and syphilis have the potential to increase the morbidity and mortality. The study was undertaken to find out the Seroprevalence of HIV in suspected individual for the years 2009 - 2010 & to randomly selected every fourth HIV positive serum sample as material for further study,  to assess the age & gender of the HIV positive persons, to find out the route of transmission / acquisition of HIV in the subjects, to identify the category of high risk groups that the HIV positive individuals fall into, to determine the seroprevalence of co-infection of  HBV, HCV and VDRL in HIV positive subjects. This prospective study included an analysis of limited serological markers for Hepatitis B and C viruses, syphilis in HIV positive individuals. The total number of blood samples received for detection of HIV antibodies was 17105 during one year, of which 417 samples were reactive  for  either HIV- I only or HIV I & II. The HIV positive rate was 2.43%. The study was conducted on 104 serum samples reactive for HIV. Every 4^th HIV reactive sample was included in the study. Therefore the total number of HIV positive samples included in the study was 104. Age wise distribution of HIV positive patients whose samples were included in the study showed that 54.8% belong to the age group 30-44 years and 26.9% belongs to 45 and above age group. Males accounted for 60.5% while 39.4% were females. The male to female ratio being 1.5:1. The commonest route of HIV transmission in our study was found to be sexual (73.07%). Individuals with various STDS 52%, CSW’s and unknown formed the majority of the high risk groups, Unknown 23.07%, CSW 20.19% respectively. Men having sex with men accounted for 2.88% of the total. Seroprevalence of three STD’s in the study group was HbsAg 5(4.8%), HCV antibodies 2 (1.9%), VDRL reactive cases 7(6.7%). In our study no combined association of Hepatitis marker and syphilis in the HIV positive cases were found. None of the  individual showed a dual or combined presence of all 3 markers (HBV + HCV + VDRL positivity). The present study showed that HIV infected individuals have a increased risk of getting coinfection with either Syphilis, HBV and / or HCV. Sexual transmission of both HBV and HCV also appears to be significant. Hence, timely treatment of these infections in HIV infected individual will decrease the  complications associated with hepatitis viruses as well as the  morbidity and mortality.

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