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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(8): 677-689
DOI: http://dx.doi.org/10.20546/ijcmas.2016.508.077


Effect of Bisphenol-A on Brain Tissue in Pregnant Rat
T.  Geetharathan*
Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam,Tirupati-517502, Andhra Pradesh, India  
*Corresponding author
Abstract:

For more than ten years, there has been a scientific and journalistic controversy whether BPA causes adverse effects on human. Humans are routinely exposed to BPA, an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. In order to study the effects of BPA on the organ of pregnant rat brain, the albino rats were administrated to low& high concentrations of BPA (50 mg/kg. d & 500 mg/kg. d). We aimed to study the toxic effect of BPA on the body & brain weight, developmental structure of cerebellum in albino pregnant rat. After 8 days (Doses were administrated gestational day 8th to 15th), the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and glutathione (GSH) concentrations in the organ was measured. Results showed that the MDA contents were increased with the added concentration of the BPA. But the SOD, CAT, GSH content was decreased. BPA induction also caused histopathological changes in the rat brain and cerebellum. All BPA treatment also revealed an increase in DNA fragmentation as evidenced by an increase in concentration of dose. It is indicated BPA can induce the rat’s oxidative damage and the effect is much easier for the brain.


Keywords: BPA,Pregnant rat,Brain,Cerebellum,MDA, GSH.
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How to cite this article:

Geetharathan, T., 2016. Effect of Bisphenol- A on Brain Tissue in PregnantInt.J.Curr.Microbiol.App.Sci. 5(8): 677-689. doi: http://dx.doi.org/10.20546/ijcmas.2016.508.077