National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Earliest detection of dengue infection and its complications in our resource-poor country is a grave challenge. It certainly reduces dengue associated mortality and morbidity. For this purpose, we set out to determine if the dengue NS1 antigen ELISA could be used as a point of care test to predict severe disease. 356 clinically suspected dengue patients with h/o<5days fever admitted in a tertiary care hospital were enrolled in this study. Clinical and laboratory parameters were recorded and the serum samples were tested using Panbio Dengue Early Elisa kit (Panbio, Australia) for detection of dengue NS1 antigen. In the study group (N=356), 25.28% were found to be reactive for dengue NS1 antigen. Maximum Seropositivity (55.56%) was seen in the age group of 15-45 years with the male:female ratio=2:1. Clinical features were significantly correlated with dengue seropositivity. 92.22% seropositive patients were found to be thrombocytopenic. It was highly significant (p<0.001). Dengue NS1 antigen is an important marker for early diagnosis of dengue infection, especially in the window period when dengue antibodies are not available in blood. Thrombocytopenia is an accessory laboratory finding to predict the impending complications (DHF, DSS).
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