Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(8): 669-676
DOI: http://dx.doi.org/10.20546/ijcmas.2016.508.076


Dengue NS1 Antigen – An Important Early Diagnostic Tool for Diagnosis of Dengue Infection
Shanta Shubhra Das*, Dilip Turbadkar, Sujata Baveja, Chaya A. Kumar, Mrudul Randive and Anita Ramchandran
Department of Microbiology, Lokmanya Tilak Municipal Medical College & GH,Sion, Mumbai, Maharashtra, PIN - 400 022, India
*Corresponding author
Abstract:

Earliest detection of dengue infection and its complications in our resource-poor country is a grave challenge. It certainly reduces dengue associated mortality and morbidity. For this purpose, we set out to determine if the dengue NS1 antigen ELISA could be used as a point of care test to predict severe disease. 356 clinically suspected dengue patients with h/o<5days fever admitted in a tertiary care hospital were enrolled in this study. Clinical and laboratory parameters were recorded and the serum samples were tested using Panbio Dengue Early Elisa kit (Panbio, Australia) for detection of dengue NS1 antigen. In the study group (N=356), 25.28% were found to be reactive for dengue NS1 antigen. Maximum Seropositivity (55.56%) was seen in the age group of 15-45 years with the male:female ratio=2:1. Clinical features were significantly correlated with dengue seropositivity. 92.22% seropositive patients were found to be thrombocytopenic. It was highly significant (p<0.001). Dengue NS1 antigen is an important marker for early diagnosis of dengue infection, especially in the window period when dengue antibodies are not available in blood. Thrombocytopenia is an accessory laboratory finding to predict the impending complications (DHF, DSS).


Keywords: Dengue,Early detection, NS1antigen, Demographic profile, Point of care test.
Download this article as Download

How to cite this article:

Shanta Shubhra Das, Dilip Turbadkar, Sujata Baveja, Chaya A. Kumar, Mrudul Randive and Anita Ramchandran. 2016. Dengue NS1 Antigen – An Important Early Diagnostic Tool for Diagnosis of Dengue InfectionInt.J.Curr.Microbiol.App.Sci. 5(8): 669-676. doi: http://dx.doi.org/10.20546/ijcmas.2016.508.076