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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(5): 2509-2517
DOI: https://doi.org/10.20546/ijcmas.2018.705.289


Prevalence of Inducible Clindamycin Resistance among Nasal Carriage Staphylococcus aureus among Healthy Population
Manish Kumar Diwakar1, Ankur Goyal2*, Santosh Verma3 and Neha Srivastava4
1Department of Microbiology, MLB Medical College, Jhansi (UP), India
2Department of Microbiology, SN Medical college, Agra, India
3Department of Community Medicine, MLB Medical College, Jhansi (UP), India
4Department of Microbiology, Rama Medical College, Kanpur (UP), India

*Corresponding author
Abstract:

The increasing resistance to many antimicrobial agents is seen in Staphylococcus aureus in all healthcare facilities. The commonest antibiotic for the treatment of the Methicillin and multi drug resistant Staphylococcal infections is clindamycin. Emergence of these resistances in Staphylococcus aureus has resulted in failure of clindamycin therapy. A total 220 Nasal swabs from healthy persons were collected and processed by standard microbiological procedures. Staphylococcus aureus was isolated in 48 cases (21.82 %) among which 6.25% were Methicillin resistance. All the Staphylococcus aureus isolates were sensitive to Amikacin, mupiriocin, teicoplanin, vancomycin and linezolid (100%). Ampicillin was the most resistant (54%) antibiotic followed by Erythromycin (40%), ciprofloxacin (33%), cotrimoxazole (31%), Ampicillin calvulanic acid (23%), clindamycin (17%) and chloramphenicol (15%), gentamycin (10%), levofloxacin (8%) and doxycycline (2%). Inducible clindamycin resistance among S. aureus isolates was 6.25%. The percentage of inducible clindamycin resistance was higher (66.67%) among MRSA compared to MSSA (2.23%). The D-test is a simple and effective tool for the phenotypic detection of inducible clindamycin resistance in S. aureus. It should be taking forward in routine practice for proper patient management and empirical therapy guideline.


Keywords: Staphylococcus aureus, MRSA, Nasal carriage, Inducible clindamycin resistance, D-test
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How to cite this article:

Manish Kumar Diwakar, Ankur Goyal, Santosh Verma and Neha Srivastava. 2018. Prevalence of Inducible Clindamycin Resistance among Nasal Carriage Staphylococcus aureus among Healthy Population.Int.J.Curr.Microbiol.App.Sci. 7(5): 2509-2517. doi: https://doi.org/10.20546/ijcmas.2018.705.289