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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(8): 564-570
DOI: http://dx.doi.org/10.20546/ijcmas.2016.508.062


GeneXpert MTB/RIF Sputum MTB Detection and Human Immunodeficiency Virus Seroprevalence among Patients with Presumptive Pulmonary Tuberculosis at a New Teaching Hospital in North-Central Nigeria
T.P. Mbaave1*, T.J. Igbudu2, L. Egwuda2, O. Audu3 and G.T. Jombo4
  1Department of Medicine, Benue State University Teaching Hospital Makurdi,
Benue State Nigeria  
 2Department of Family Medicine, Benue State University Teaching Hospital Makurdi,Benue State Nigeria
3Department of Epidemiology and Community Medicine, Benue State University Teaching Hospital Makurdi, Benue State Nigeria
4Department of Medical Microbiology, Benue State University Teaching Hospital
Makurdi, Benue State Nigeria  
*Corresponding author
Abstract:

The GeneXpert MTB/RIF (GeneXpert) test, a nucleic acid amplification test for the diagnosis of pulmonary tuberculosis in both HIV seronegative and serpositive patients is gradually replacing sputum smear microscopy even in resource-constrained developing nations. To assess the prevalence of GeneXpert sputum positive TB and sero-prevalence of human immunodeficiency virus (HIV) among patients with presumptive pulmonary tuberculosis (PTB) in a teaching hospital in North central Nigeria. This was an operational based prospective laboratory study carried out from Febraury, 2014 to May, 2015 at the Benue State University Teaching Hospital, Makurdi, North-central Nigeria. The GeneXpert technology and Determine/Stat pak were used for the diagnosis of PTB and HIV respectively. Three hundred (300) presumptive PTB cases were recruited, 160 (53.3%) were males and 140 (46.7%) were females. Mean age of 39.81 years. Seventy (23.3%) tested positive for PTB. More than half (56.3%) were positive for HIV with females most vulnerable. PTB/HIV co-infection was found in 34/300 (11.33%) of the patients. The positivity for PTB, HIV and co-infection were all skewed to age group of 31-40 years. The study revealed a high prevalence of GeneXpert sputum positive PTB, HIV and co-infection among presumptive PTB cases in Makurdi.


Keywords: Sputum MTB Detection,Human Immunodeficiency Virus,
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How to cite this article:

Mbaave, T.P., T.J. Igbudu, L. Egwuda, O. Audu and Jombo, G.T. 2016. GeneXpert MTB/RIF Sputum MTB Detection and Human Immunodeficiency Virus Seroprevalence among Patients with Presumptive Pulmonary Tuberculosis at a New Teaching Hospital in North-Central Nigeria.Int.J.Curr.Microbiol.App.Sci. 5(8): 564-570. doi: http://dx.doi.org/10.20546/ijcmas.2016.508.062