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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(5): 1236-1247
DOI: https://doi.org/10.20546/ijcmas.2018.705.150


Significance of C - Reactive Protein and Routine Analysis of Cerebrospinal Fluid in Children with Meningitis
Jagadevi1, B. Saipriya1*, K.R. Madhuri1, Anjana Gopi2 and Jagadeesh2
1Department of Microbiology, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, India
2Department of Microbiology, Kempegowda Institute of Medical sciences, Bangalore, Karnataka, India
*Corresponding author
Abstract:

A 2-year prospective study was carried out on 110 children with clinical suspicion of meningitis where C-reactive protein (CRP) determination and routine cytochemical and microbiological analysis of Cerebrospinal fluid (CSF) were done for all patients. The patients were divided into four groups: Pyogenic meningitis (PM), viral meningitis (VM), tubercular meningitis (TBM) and control groups. Among 110 cases of suspected meningitis, there were 62(56.36%) cases of meningitis, out of which 21 (19.09%) were PM, 35(31.81%) were VM, 06 (5.45%) were TBM and the remaining 48 (43.63%) were controls. Out of 21 cases of PM, CSF culture was positive in 9 (42.85%), Latex agglutination test detected antigen in 14 (66.66%) and Gram staining showed organisms in 13 (61.90%). S.pneumoniae was the leading pathogen of PM, CSF LAT detected 6/21(28.57%) and CSF culture isolated 3/21(14.28%) S. pneumoniae. The mean value of CSF CRP were 15.167±4.925 in PM, 3.667±1.779 in TBM, and 2.557±0.998 in VM. Statistically highly significant value (p < 0.001) was observed when the mean of PM compared with other two groups. Quantitative estimation of CSF CRP is an easy and reliable, screening tool can be used for diagnosis of PM and to rule out VM or TBM in cases of uncertain diagnosis with high level of sensitivity and specificity.


Keywords: Meningitis, C-reactive protein, Cerebrospinal fluid, Children
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How to cite this article:

Jagadevi, B. Saipriya, K.R. Madhuri, Anjana Gopi and Jagadeesh. 2018. Significance of C - Reactive Protein and Routine Analysis of Cerebrospinal Fluid in Children with Meningitis.Int.J.Curr.Microbiol.App.Sci. 7(5): 1236-1247. doi: https://doi.org/10.20546/ijcmas.2018.705.150