National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
A 2-year prospective study was carried out on 110 children with clinical suspicion of meningitis where C-reactive protein (CRP) determination and routine cytochemical and microbiological analysis of Cerebrospinal fluid (CSF) were done for all patients. The patients were divided into four groups: Pyogenic meningitis (PM), viral meningitis (VM), tubercular meningitis (TBM) and control groups. Among 110 cases of suspected meningitis, there were 62(56.36%) cases of meningitis, out of which 21 (19.09%) were PM, 35(31.81%) were VM, 06 (5.45%) were TBM and the remaining 48 (43.63%) were controls. Out of 21 cases of PM, CSF culture was positive in 9 (42.85%), Latex agglutination test detected antigen in 14 (66.66%) and Gram staining showed organisms in 13 (61.90%). S.pneumoniae was the leading pathogen of PM, CSF LAT detected 6/21(28.57%) and CSF culture isolated 3/21(14.28%) S. pneumoniae. The mean value of CSF CRP were 15.167±4.925 in PM, 3.667±1.779 in TBM, and 2.557±0.998 in VM. Statistically highly significant value (p < 0.001) was observed when the mean of PM compared with other two groups. Quantitative estimation of CSF CRP is an easy and reliable, screening tool can be used for diagnosis of PM and to rule out VM or TBM in cases of uncertain diagnosis with high level of sensitivity and specificity.
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