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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(8): 414-421
DOI: http://dx.doi.org/10.20546/ijcmas.2016.508.044


In Vitro Cytotoxicity Effect of Kaempferol in Breast Cancer Cell Lines MCF-7 and Lung Cancer Cell Lines A459
Ramesh L. Londonkar* and Basavarajeshwari S. Awanti
 Dept of Biotechnology, Gulbarga University, Gulbarga-585105 Karnataka, India
*Corresponding author
Abstract:

In this study cytotoxic effect of kaempferol isolated from Vigna unguiculata was evaluated on breast cancer (MCF-7) and lung cancer A459 cell lines. MCF-7 and A459 cells were cultured in DMEM medium and incubated with different concentrations (100, 50, 25, 12.5, 6.25 µg/ml) of kaempferol .The   cell viability was assessed by MTT assay. Kaempferol has decreased malignant cells in a concentration dependent manner. The IC50 values in MCF-7 and A459 cells were determined as 90.28 ± 4.2 µg/ml and 35.80 ± 0.4 µg/ml respectively.  It may be concluded that kaempferol can cause cell death in MCF-7 and A459 cancer cells which is considered as a promising chemotherapeutic agent in breast cancer and lung cancer treatment.


Keywords: Kaempferol, cytotoxicity effect, breast cancer,lung cancer.
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How to cite this article:

Ramesh L. Londonkar and Basavarajeshwari S. Awanti. 2016. In Vitro Cytotoxicity Effect of Kaempferol in Breast Cancer Cell Lines MCF-7 and Lung Cancer Cell Lines A459.Int.J.Curr.Microbiol.App.Sci. 5(8): 414-421. doi: http://dx.doi.org/10.20546/ijcmas.2016.508.044