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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(8): 394-401
DOI: http://dx.doi.org/10.20546/ijcmas.2016.508.042


Antimycobacterial Activity of Norbornene-Polyethylene Glycol, Isoniazid and Rifampicin Nanocarrier towards Mycobacterium tuberculosis
K.Kalaiselvi1, V. Mangayarkarasi1*, N.S. Gomathi2, R.M. Shivshankar3 and Raja Shunmugam3
1Department of Microbiology, SRM Medical College Hospital and Research Centre (SRM MCH&RC), Kancheepuram, Tamil Nadu, India
2Department of Bacteriology, National Institute for Research in Tuberculosis (NIRT),Chetpet, Tamil Nadu, India
3Polymer Research Centre, Department of Chemical Science, Indian Institute of Science Education and Research Kolkata (IISER K), Mohanpur 741246, India
*Corresponding author
Abstract:

The digital world that we live today is filled with innovations and advanced technologies, but still the role of medical sectors in preventing infectious diseases like Tuberculosis is feeble- minded. One of the advanced technologies so called Nanotechnology plays a vital role in research for the diagnosis and treatment of Tuberculosis, thus preventing side effects and drug resistance. The present study aimed at evaluating, Norbornene derived Isoniazid Co polymer (NOR-PEG-INH) and Norbornene derived Rifampicin Co polymer (NOR-PEG-RIF), a novel nanocarrier along with the drug for Tuberculosis with targeted drug delivery and longer bioavailability. The nanocarrier along with the drug preparation and their property were studied by the collaborated institute, Indian Institute of Science Education and Research (IISER) by covalent binding method. The invitro activity of the drug was evaluated using absolute concentration method to observe the Mininium Inhibitory Concentration (MIC) of the drug against H37Rv control strain of Mycobacterium tuberculosis (MTB) and clinical isolates of Mycobacterium tuberculosis from patient samples. The results showed that NOR-PEG-INH and NOR-PEG-RIF, the nanocarriers of Isoniazid and Rifampicin were able to show the lower MIC to inhibit Mycobacterium tuberculosis.


Keywords: Norbornene, Polyethylene Glycol, Covalent binding, Nanocarrier, Isoniazid, Rifampicin.
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How to cite this article:

Kalaiselvi, K., V. Mangayarkarasi, N.S. Gomathi, R.M. Shivshankar and Raja Shunmugam. 2016. Antimycobacterial Activity of Norbornene-Polyethylene Glycol, Isoniazid and Rifampicin Nanocarrier towards Mycobacterium tuberculosisInt.J.Curr.Microbiol.App.Sci. 5(8): 394-401. doi: http://dx.doi.org/10.20546/ijcmas.2016.508.042