International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:8, August, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(8): 156-163

Glutathione S-Transferase (GSTM1, GSTT1) Genes Polymorphisms Associated with Vitiligo Disease in Thi Qar Province/South of Iraq
Hayder Hussein Jalood1, Hassan R. AL-Rikabi2, Adnan Issa Al-Badran3*, and Ahmed Abdulhussein Kawen4
1Department of Pharmacy- Mazaya University College, Iraq
2Department of Biology - College of Pure Education - University of Thi Qar, Iraq
3Department of Biology, Cell and Biotechnology Research Unit, College of science,University of Basrah, Iraq
4Al-Hussein Hospital, Thi Qar Health Directorate, Iraq
*Corresponding author

Vitiligo is a common skin disease caused by a deficiency in the production of melanocyte. It is a non-contagious disease that affects the general public, without distinction of race, sex. The aim of this study was to find the clinical features and evaluate the association between GSTT1, GSTM1 null genotypes and the development of vitiligo in Dhi Qar province in southern Iraq. This study included 100 vitiligo patients and 90 controls (mean age 32±15.2, 31.8±11.2 respectively). 80% of patients were males while rest 20% were females. Vitiligo does not show any significant association with smoking. 35% patients are associated with the positive family history. 12% cases reported physical trauma as the physical factor. 10% patients were associated with autoimmune disease. Polymerase Chain Reaction PCR was used for the analysis of the study  null genotypes. We found that the GSTM1-null might play an important role in risk for vitiligo (OR=1.56; 95%CI =0.88-2.79), and the GSTT1-null genotype was significantly associated with the susceptibility to vitiligo (OR=1.55; 95 % CI= 0.79-3.06). In combined analysis GSTT1, GSTM1 null genotypes showed significant associations with vitiligo susceptibility (OR=2.70; 95%, CI=1.03-7.08).

Keywords: Vitiligo, polymorphism, glutathione S-transferase, Polymerase Chain Reaction.

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How to cite this article:

Hayder Hussein Jalood, Hassan R. AL-Rikabi, Adnan Issa Al-Badran and Ahmed Abdulhussein Kawen. 2016. Glutathione S-Transferase (GSTM1, GSTT1) Genes Polymorphisms Associated with Vitiligo Disease in Thi Qar Province/South of Iraq.Int.J.Curr.Microbiol.App.Sci. 5(8): 156-163. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.