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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(4): 2186-2192
DOI: https://doi.org/10.20546/ijcmas.2018.704.248


Effect of Spinosad and Imidacloprid on Serum Biochemical Alterations in Male Broilers and Its Amelioration with Vitamin E and Silymarin
V. Ravikanth1*, M. Lakshman2, D. Madhuri3 and B. Kalakumar4
1Veterinary Assistant Surgeon, Department of Animal Husbandry, Telangana, India
2RUSKA Labs, Department of Veterinary Pathology, C.V.Sc, Hyderabad, Telangana, India
3Department of Veterinary Pathology, C.V.Sc, Hyderabad, Telangana, India
4Department of Veterinary Pharmacology and Toxicology, C.V.Sc, Hyderabad, Telangana, India
*Corresponding author
Abstract:

The present experiment was conducted on 120 male broiler chicks which were divided into six groups of 20 each. Group 1 served as control, group 2 treated with imidacloprid @ 50 ppm in feed, group 3 was treated with spinosad @ 1000 ppm in feed, group 4 was treated with imidacloprid @ 50 ppm and spinosad @ 1000 ppm in feed, group 5 was treated with imidacloprid @ 50 ppm, spinosad @ 1000 ppm and Vitamin E @ 20 ppm in feed and group 6 was treated with imidacloprid @ 50 ppm, spinosad @ 1000 ppm and silymarin @ 1000 ppm in feed. The experiment was carried out for 4 weeks. The blood samples were collected for separation of serum to analyze various biochemical parameters on 14 and 28 days after oral administration the compounds mentioned above. The biochemical assays showed a significant (P < 0.05) increase in serum ALP, significant (P < 0.05) decrease in serum total protein, insignificant decrease in serum AChE and an insignificant increase in serum ACP in all groups when compared to control. Group 5 and 6 showed numerically decreased values of serum ALT and increase in TP when compared to group 4. Liver tissue biochemical profile revealed a significant (P < 0.05) reduction in GSH concentration in liver of group 2, 3 and 4 and a mild to moderate improvement was noticed in group 5 and 6 when compared to group 4. These results revealed that exposure of Imidacloprid, spinosad and its combination resulted in alterations in serum and tissue biochemical parameters.


Keywords: Imidacloprid, Spinosad, Toxicity, Histopathology
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How to cite this article:

Ravikanth, V., M. Lakshman, D. Madhuri and Kalakumar, B. 2018. Effect of Spinosad and Imidacloprid on Serum Biochemical Alterations in Male Broilers and Its Amelioration with Vitamin E and Silymarin.Int.J.Curr.Microbiol.App.Sci. 7(4): 2186-2192. doi: https://doi.org/10.20546/ijcmas.2018.704.248