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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 912-923
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.103


Prevalence and Antimicrobial Susceptibility Pattern of Extended Spectrum Beta-Lactamse Producing Escherichia coli and Klebsiella pneumoniae Isolated at a Tertiary Care Institute in North West Region of Rajasthan, India
Bhagirath Ram Bishnoi1, Abhishek Binnani1 and Priyanka Soni Gupta2*
1Department of Microbiology, S. P. Medical College, Bikaner, Rajasthan, India
2Department of Microbiology, Jawahar Lal Nehru Medical College, Ajmer, Rajasthan, India
*Corresponding author
Abstract:

The incidence of extended spectrum beta lactamase producing strains among clinical isolates has been steadily increasing over the past few years resulting in limitation of therapeutic options available.8,16Therefore we conducted this study to determine the prevalence and antibiotic susceptibility pattern of ESBL producers among  Escherichia coli and  Klebsiella pneumoniae  isolates in the north west region of the state, as the prevalence and antimicrobial susceptibility of ESBL-producing pathogens varies from one region to another. This study was carried out in the Department of Microbiology, Sardar Patel Medical college, Bikaner from April 2009 to May 2010 on a total of 700 clinical isolates including 520 Escherichia coli and 180 Klebsiella pneumoniae. In the present study ESBL production was noticed in 65.57% isolates with maximal incidence in Escherichia coli (66.92%) followed by Klebsiella pneumoniae (61.67%) isolates. The antimicrobial resistance was significantely higher in ESBL producer than non-ESBL producer. Among ESBL producer high rate of resistance to various antibiotics was seen (cefotaxime, ceftazidime, ceftriaxone, norfloxacin, cotrimoxazole). These high rates of resistance to various antibiotics may be due to various factors like-plasmid mediated transmission of ESBLs, poorly directed therapy and over-the-counter sales of antibiotics.


Keywords: ESBL,beta-lactamases, resistance,Escherichia coli,Klebsiella pneumoniae
 
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How to cite this article:

Bhagirath Ram Bishnoi, Abhishek Binnani and Priyanka Soni Gupta. 2016. Prevalence and Antimicrobial Susceptibility Pattern of Extended Spectrum Beta-Lactamse Producing Escherichia coli and Klebsiella pneumoniae Isolated at a Tertiary Care Institute in North West Region of Rajasthan, IndiaInt.J.Curr.Microbiol.App.Sci. 5(7): 912-923. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.103