National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by hormonal imbalances. The syndrome is suspected as autoimmune disease. The process of secretion mediated by Fucosyltransferase2 is an essential step in generating gonadotropins hormones, like Follicle stimulating hormone (FSH) that is central to the process of cystic change in the ovary. In this study, one hundred hormonally and clinically characterized polycystic ovary syndrome (PCOS) patients ranging in age from 18-44 years and fifty appearently healthy controls were enrolled. The patients and controls were saliva typed for Lewis secretors and non-secretors. The results emerged from this study reveal the followings: Demographic data indicated an incidence age of 26.5±4.53 in patients versus28.54±6.07 in controls (p=0.022). FSH/LH ratio was 0.91±0.61 in patients and was 2.18±2.35 in controls. Overall-patients and controls secretors gave about identical frequency approaching 87and 90% in patients and controls respectively. The level of H-substance in saliva (FUT2 enzyme activity) didn´t differ in patients and controls (43.6±70.5) in patients versus 43.95±62.64 in controls (p= 0.98). Sorting out secretors to Leb and Lea-b- secretors gave a decreased 28.65 mean titer in patients versus 40.12 titer in controls. The conclusion drawn from the findings presented in this communication is that there is no role of Fucosyltransferase2 gene product that is associated with polycystic ovary syndrome.
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