National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Pharmacokinetics of meloxicam was studied following its single dose intraperitoneal administration alone and administered with erlotinib and/or metformin in SCID mice. The plasma concentration of meloxicam was assayed by LC-MS/MS. Following administration of meloxicam as single drug in male SCID mice, the mean values of observed peak plasma drug concentration (Cmax), time of maximum concentration (Tmax), area under plasma drug concentration-time curve (AUC0-ï‚¥), volume of distribution (Vz), half-life (t½) and total body clearance (Cl) were 45715.22 ± 3343.07 ng/mL, 0.40 ± 0.09 h, 123999.94 ± 4181.79 ng.h/mL, 873.90 ± 59.61 ml, 3.79 ± 0.34 h and162.24 ± 5.67 ml/h, respectively. When erlotinib and/or metformin were administered with meloxicam in SCID mice, significant alterationin pharmacokinetic parameters of meloxicam were observed. Thus, pharmacovigilance should be followed for the concomitant administration of these drugs for prolong period. However, clinical pharmacokinetic interaction of these drugs in human needs to be evaluated.
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