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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2018) [Effective from January 1, 2018]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2016: 92.3
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2016: 92.30
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 660-669
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.075


Occult and Chronic Hepatitis B Infection: Relation of Viral Load to Serum Level of 25 Hydroxy Vitamin D
Mervat Mashaly1*, Eman EL Sayed1, Gehaan A. Shaker2, Rokiah Anwar3, Neven Farouk Abbas3, Sahar Zakaria4 and Enaase A.M.E. Barakat3
1Clinical Pathology Department, Faculty of Medicine, Mansoura University-Egypt
2Physiology department, Faculty of Medicine, Mansoura University-Egypt
3Internal Medicine Department, Faculty of Medicine, Mansoura University-Egypt
4Tropical Medicine Department, Faculty of Medicine, Mansoura University-Egypt
*Corresponding author
Abstract:

Recent evidence from various lines of research suggested that low levels of vitamin D are associated with high levels of hepatitis B virus (HBV) replication in chronic hepatitis B (CHB) infection. However, the relationship between vitamin D and occult hepatitis B infection (OBI) remains unclear. To investigate the pattern of 25 hydroxy vitamin D levels in patients with OBI, we compared serum level of vitamin D among 52 patients with CHB infection, 16 patients with OBI and 34 age & sex matched healthy control. Hepatitis B envelope (HBe) antigen was assayed among CHB patients. Also, we quantified HBV DNA viral load among both CHB and OBI groups by using Real time PCR. We found that serum level of vitamin D was significantly higher in patients with OBI than those with CHB infection but it was insignificantly differ from healthy control. Patients with HBe Ag negative had a significantly higher serum level of vitamin D than those with HBe Ag positive. Serum level of vitamin D was inversely correlated with HBV DNA viral load. It could be concluded that adequate levels of vitamin D may be one of the factors limiting the replication of HBV and decreasing viral load in patients with OBI.


Keywords: Occult hepatitis B virus infection, 25 hydroxy vitamin D, Chronic hepatitis B infection, Hepatitis B virus DNA, Real time PCR.
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How to cite this article:

Mervat Mashaly, Eman EL Sayed, Gehaan A. Shaker, Rokiah Anwar, Neven Farouk Abbas, Sahar Zakaria and Enaase A.M.E. Barakat. 2016. Occult and Chronic Hepatitis B Infection: Relation of Viral Load to Serum Level of 25 Hydroxy Vitamin D.Int.J.Curr.Microbiol.App.Sci. 5(7): 660-669. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.075