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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(3): 1311-1316
DOI: https://doi.org/10.20546/ijcmas.2018.703.156


Detection of Human Leukocyte Antigen (HLA) B27 among Patients of Seronegative Spondyloarthropathies Referred to a Tertiary Care Center
V. Uma Maheshwari*, V.P. Amudha, G. Sucilathangam and C. Revathy
Department of Microbiology, Tirunelveli Medical College, Tirunelveli - 627 011, Tamil Nadu, India
*Corresponding author
Abstract:

Human leukocyte antigen B27 (HLA-B27), a class I molecules of the major histocompatibility complex has a strong disease association with different types of spondarthropathies (SpA). The strength of this disease association varies markedly among racial and ethnic populations. The present study aimed to detect the frequency of HLA B27 Antigen among Seronegative Spondyloarthropathy (SpA) patients by PCR. The study was conducted over a period of one year. A total of 40 blood samples were collected from suspected Spondyloarthropathy subjects, these blood samples were subjected to HLA B27 detection by PCR. The results were analyzed. 20% of subjects in study group were HLA B27 positive. So prevalence of HLA B27 in Spondyloarthropathy in this region is 20%. This study highlights the prevalence of HLA B27 antigen in Seronegative Spondyloarthropathy patients, strength of association is more between HLA B27 antigen and Spondyloarthropathy. HLA typing is helpful in early diagnosis of SpA before the development of Radiological features. Detection of HLA B27 is important for institution of early treatment and to investigate for other manifestations of Spondyloarthropathy. It is also useful in screening of other family members for HLA B27. HLA typing is also important to exclude other causes of inflammatory arthritis.


Keywords: HLA B27, Spondyloarthropathy, HLA B27 PCR
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How to cite this article:

Uma Maheshwari, V., V.P. Amudha, G. Sucilathangam and Revathy, C. 2018. Detection of Human Leukocyte Antigen (HLA) B27 among Patients of Seronegative Spondyloarthropathies Referred to a Tertiary Care CenterInt.J.Curr.Microbiol.App.Sci. 7(3): 1311-1316. doi: https://doi.org/10.20546/ijcmas.2018.703.156