National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Non fermenter Gram negative bacilli were considered as contaminants or commensals of little significance1. However, recent literature review shows that these organisms are now associated with life-threatening infections such as Septicemia, Pneumonia, Urinary Tract Infection, Meningitis, Surgical Site Infection, Ventilator Associated Pneumonia, Wound Infection, Osteomyelitis etc. Carbapenemases are diverse enzymes that vary in their ability to hydrolyze Carbapenems and other beta lactams. Detection of Carbapenemase is a crucial infection control issue because they are often associated with extensive antibiotic resistance, treatment failures and infection‑ associated mortality. A total of 100 isolates of Non Fermenter Gram Negative Bacilli were isolated from specimens of Respiratory Tract Infection, Wound Infection, Urinary Tract Infections, Septicemia, Post Operative Wound Infections, Ear Infections. The isolated NFGNB were subjected to Meropenem resistance by disc diffusion test and those strains which show resistance to Meropenem were subjected to Carbapenamase detection method by using, Double disc synergy test, combination disc method and MBL E test. Among the 100 Non fermenter isolates, 87 were Pseudomonas aeruginosa and 13 were Acinetobacter baumanii. Screening with Meropenem disk showed 32% of isolates were positive for Carbapenem resistance. Among them CDT detected 59.3%, DDST 50% and E test 46.8% of the MBL producer. 13 MDR NFGNB were detected among the 32 isolates. The proper identification of NFGNB up to the species level together with monitoring their susceptibility patterns are mandatory for proper management of infections caused by these pathogens.
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