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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 503-512
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.055


Characterization of Micro RNA Signature in Peripheral Blood of Schizophrenia Patients using µParafloTM miRNA Microarray Assay
Tihomir I. Vachev1,3*, Nikolay T. Popov2, Danail Marchev1, Hristo Ivanov4 and Vili K. Stoyanova3,4
1Department of Plant Phisyology and Molecular Biology, University of Plovdiv “Paisii Hilendarski”, 24 Tzar Assen Str., Plovdiv, Bulgaria
2Psychiatric ward for active treatment of men, State Phsychiatry Hospital Pazardzhik, 28 Bolnichna Str. 4400 Pazardzhik, Bulgaria
3University Hospital “St. George” Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria
4Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov 15-A Str., Plovdiv 4002, Bulgaria
*Corresponding author
Abstract:

Development of biomarkers for psychiatric disease still remains challenging. Recently, numerous alterations in the expression of microRNAs (miRNAs) in peripheral blood, serum and post-mortem brain tissue have been linked to schizophrenia. Additionally, it is known that miRNAs can inactivate a target mRNA sequence through binding to its 3’UTR region. Thus, miRNAs might not only serve as prognostic biomarkers for diagnosis or prognosis of pathological conditions like schizophrenia, but could also actively modulate gene function. Therefore, the aim of this study was to test whether specific miRNA display differential expression in patients with schizophrenia vs. healthy controls by using miRNA microarray assay. Venous blood samples of 33 affected patients and 25 healthy controls were collected and the quantification of microRNAs was established using miRNA microarray assay. Moreover, we searched for potential validated target genes for each of the differentially expressed miRNAs that might play a role in the regulation of schizophrenia susceptibility genes.


Keywords: micro RNA, Peripheral Blood of Schizophrenia,miRNA Microarray Assay
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How to cite this article:

Tihomir I. Vachev, Nikolay T. Popov, Danail Marchev, Hristo Ivanov and Vili K. Stoyanova. 2016. Characterization of Micro RNA Signature in Peripheral Blood of Schizophrenia Patients using µParafloTM miRNA Microarray AssayInt.J.Curr.Microbiol.App.Sci. 5(7): 503-512. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.055