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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(2): 2759-2766
DOI: https://doi.org/10.20546/ijcmas.2018.702.336


Effect of Ethanol Root and Leave Extracts of Sida acuta on Some Kidney Function Indices and Electrolytes in Albino Wistar Rats
P. Nwankpa1*, C.C. Etteh2, C.N. Ekweogu1, P.C. Chikezie3, O.G. Chukwuemeka4 and J.N. Egwurugwu5
1Department of Medical Biochemistry, Imo State University, Owerri Nigeria
2Department of Biochemistry, Coventry University United Kingdom
3Department of Biochemistry, Imo State University, Owerri Nigeria
4Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria
5Department of Physiology, Imo State University, Owerri Nigeria
*Corresponding author
Abstract:

This study investigates the effect of ethanol root and leaf extracts of Sida acuta on some kidney function indices and electrolytes in albino wistar rats. The rats were divided into 4 groups of 7 rats each. Group 1 was the control group, group II received an oral dose of 100 mg/kg leaf extract of Sida acuta daily, group III received an oral dose of 100 mg/kg root extract of Sida acuta daily while group IV received 50 mg/kg each of leaf extract and root extract of Sida acuta daily. After 21 days of treatment, the rats were sacrificed and standard analytical methods were used to assay the biochemical indices. The result of creatinine (mol/L) showed a significant (P<0.05) increase in a dose dependent manner in the treatment groups (10.20 ± 0.25, 11.8 ± 0.26, 12. 55 ± 0.16) compared to the control (5.48 ± 0.76) while urea (mol/L) showed a significant (P<0.05) decrease in treatment groups (2.54 ± 0.43, 3.75 ± 0.29, 4.08 ± 0.61) compared to the control (8.53 ± 0.33). The electrolytes (Na+, Cl- and HCO3-) showed a significant (P<0.05) decrease in the treatment groups compared to the control while K (mmol/L) was not significant (P>0.05) compared to the control. The kidney ALT and ALP (lU/L) in treatment groups revealed a significant (P<0.05) decrease while AST (lU/L) showed a significant, (P<0.05) increase compared to control. The result of this study has shown that the administration of root and leaf extracts of Sida acuta may be toxic to the kidney which may induce renal dysfunction.


Keywords: Sida acuta, Wistar rats, Toxicity, Electrolytes, Renal dysfunction
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How to cite this article:

Nwankpa, P., C.C. Etteh, C.N. Ekweogu, P.C. Chikezie, O.G. Chukwuemeka and Egwurugwu, J.N. 2018. Effect of Ethanol Root and Leave Extracts of Sida acuta on Some Kidney Function Indices and Electrolytes in Albino Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 7(2): 2759-2766. doi: https://doi.org/10.20546/ijcmas.2018.702.336