National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
This study investigates the effect of ethanol root and leaf extracts of Sida acuta on some kidney function indices and electrolytes in albino wistar rats. The rats were divided into 4 groups of 7 rats each. Group 1 was the control group, group II received an oral dose of 100 mg/kg leaf extract of Sida acuta daily, group III received an oral dose of 100 mg/kg root extract of Sida acuta daily while group IV received 50 mg/kg each of leaf extract and root extract of Sida acuta daily. After 21 days of treatment, the rats were sacrificed and standard analytical methods were used to assay the biochemical indices. The result of creatinine (mol/L) showed a significant (P<0.05) increase in a dose dependent manner in the treatment groups (10.20 ± 0.25, 11.8 ± 0.26, 12. 55 ± 0.16) compared to the control (5.48 ± 0.76) while urea (mol/L) showed a significant (P<0.05) decrease in treatment groups (2.54 ± 0.43, 3.75 ± 0.29, 4.08 ± 0.61) compared to the control (8.53 ± 0.33). The electrolytes (Na+, Cl- and HCO3-) showed a significant (P<0.05) decrease in the treatment groups compared to the control while K (mmol/L) was not significant (P>0.05) compared to the control. The kidney ALT and ALP (lU/L) in treatment groups revealed a significant (P<0.05) decrease while AST (lU/L) showed a significant, (P<0.05) increase compared to control. The result of this study has shown that the administration of root and leaf extracts of Sida acuta may be toxic to the kidney which may induce renal dysfunction.
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