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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 275-279
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.028


Rabbit Serum Raised against P. aeruginosa Biofilm Exhibit Significant Biofilm Reduction and Removal Activity
Syed H. Abidi1,2*, Khalid Ahmed1, Fatin Zehra3, Nouman Mughal3 and Shahana U. Kazmi2
1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi-Pakistan
2Immunology and Infectious Diseases Research Lab (IIDRL), Department of Microbiology, University of Karachi, Karachi-Pakistan
3Dow University of Health Sciences, Karachi-Pakistan
*Corresponding author
Abstract:

P.aeruginosa biofilms can offer resistance to antibiotics, and have evolved mechanisms to evade innate and acquired immune systems. Biofilms infection causes stimulation of innate and acquired immune systems. However, their persistent activation may result in more immune-mediated tissue damage with limited success in the removal of the biofilm pathogen. In this study we evaluated the potential of the serum raised against P. aeruginosa biofilm antigen in reducing and removing P. aeruginosa biofilms. We raised polyclonal sera in a Rabbit against P. aeruginosa biofilm antigens. The efficacy of the antigen was tested using slide agglutination test. We finally tested the efficacy of polyclonal sera to reduce and remove biofilm formation. We found that the anti-sera from rabbit showed strong immune response and disinfection activity against P. aeruginosa biofilm antigens. Passive immunotherapies can be important in attenuating acute P. aeruginosa infection and interfering with chronic infection.


Keywords: Rabbit Serum Raised against P.aeruginosa Biofilm.
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How to cite this article:

Syed H. Abidi, Khalid Ahmed, Fatin Zehra, Nouman Mughal and Shahana U. Kazmi. 2016. Rabbit Serum Raised against P. aeruginosa Biofilm Exhibit Significant Biofilm Reduction and Removal Activity.Int.J.Curr.Microbiol.App.Sci. 5(7): 275-279. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.028