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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 3473-3485
DOI: https://doi.org/10.20546/ijcmas.2018.701.409


Human Anticancers and Antidiabetic Activities of the Cyanobacterium Fischerella sp. BS1-EG Isolated from River Nile, Egypt
Bassant E. Ahmed1, Mona H. Badawi1, Soha S. Mostafa2 and Aziz M. Higazy1*
1Department of Microbiology, Fac. Agric., Cairo University, Giza, Egypt
2Department of Microbiology, Inst. Soil, Water and Environment, ARC, Giza, Egypt
*Corresponding author
Abstract:

Cyanobacteria are known as a potential source of several metabolic compounds like phytohormons, phenols, antibiotics, anticancer, antiviral, anti-inflammatory as well as pharmaceuticals. These compounds are reported to be used in agriculture, biology and medicine. This study was performed to isolate Fischerella sp, from river Nile/ Egypt. Also, its potential to produce some bioactive compounds was evaluated. Results indicated that Fischerella BS1-EG isolate during this study has a considerable antifungal activity against Aspergillus, Fusarioum and Penicillum sp. In general, the determined fungal activities by means of inhibition zone ranged between 8.5-16mm. Regarding the cell cytotoxicity of Fischerella BS1-EG on liver cancer (HepG-2), lung cancer (A549), colon cancer (HCT-116), breast cancer (MCF-7) data revealed that Fischerella BS1-EG crude extract exhibited a variable influence on all tested cell lines GC-MS analysis showed that 29 different compounds were detected and identified as fatty acids, alkaloids, phenols, amino acids, the most important 9 compounds were identified as anticancer, antimicrobial, anti-inflammatory agents. On the other hand, Fischerella BS1-EG proved to have anti hyper glycemia activity through inhibition of α-glucosidase activity. These results may indicate that, for the first time, Fischerella BS1-EG is recorded to have different biological activities as anti-cancer as well as anti-hyperglycemia.


Keywords: Cyanobacteria, Fischerella, GC-MS, Anti-diabetic, Anti-cancer
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How to cite this article:

Bassant E. Ahmed, Mona H. Badawi, Soha S. Mostafa and Aziz M. Higazy. 2018. Human Anticancers and Antidiabetic Activities of the Cyanobacterium Fischerella sp. BS1-EG Isolated from River Nile, EgyptInt.J.Curr.Microbiol.App.Sci. 7(1): 3473-3485. doi: https://doi.org/10.20546/ijcmas.2018.701.409