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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 3466-3472
DOI: https://doi.org/10.20546/ijcmas.2018.701.408


Hormonal Balance of Hyperthyroidism in the Laboratory of Biophysics of Dakar: Proposal of a Diagnostic and Monitoring Approach
Djiby Sow1,2,3, Amadou Ndiaye2*, Boubacar Ndong4, Moussa Badiane4,Pr Oumar Ndoye4 and Pr Niama Diop Sall2,3
 
1Marc Sankhale Center, Abass NDAO Hospital in Dakar, internal medicine service (Senegal)
2Laboratory analyzes Medical Biology, Abass NDAO hospital in Dakar (Senegal)
3Faculty of Medicine, Pharmacy and Dentistry (FMPOS) in Dakar, Medical Biochemistry Laboratory
4Faculty of Medicine, Pharmacy and Dentistry (FMPOS) in Dakar, biophysical laboratory
*Corresponding author
Abstract:

Hyperthyroidism refers to a hyper functioning of the thyroid gland which increases the production of thyroid hormones because of thyrotoxicosis. Hyperthyroidism is a common endocrinopathy with multiple etiologies that can be its exploration requires a diagnostic approach consistent with the rational use of available biological means of exploration. Our aim was to determine the nature and prevalence of the principles underlying thyroid hormone demand in the investigation of clinically suspected or proven hyperthyroidism; to correlate the results of the hormonal exploration to the reasons. This study was carried out over a one-year period from April 2005 to April 2006. All requests for hormonal assays performed in the laboratory for hyperthyroidism, regardless of its etiology, were considered. thyrotoxicosis, or any other reason that may lead to the diagnosis of hyperthyroidism. One thousand four hundred and sixty (1460) patients were enrolled in the study, of whom 1293 (89%) were sex ratio 7, 74. The average age was 39 years with extremes 1 and 78 years. The 21-45 age group was the most represented with 27 cases. The origin of the patients referred for hormonal dosages was from all the geographical areas of Senegal with a predominance of the Dakar region 93%; In Dakar the requests came mainly from CHU Abass NDAO, Dantec and FANN which recorded respectively: 41%; 19.7% and 7.8%. The most common hormonal dosage indication was control of antithyroid drug therapy (ADT). 596 cases (40.8%) followed by "balance sheet" and goiter with respectively 14.6% and 12.7%; TSHus was requested in 90% of patients, FT4 81% and FT3 41%. The TSHus demand combined with FT4 and FT3 was noted for diagnosis in 680 cases (46%) and for the control of ADT treatment in 170 cases (25%). The biological diagnoses were euthyroid 39%, hyperthyroidism 30.80%, hyperthyroidism frustrated 3.4%. A discrepancy in the biological assessment was noted in 25 cases (1.7%). From these results we find that a lot of demand is not justified. These preliminary results may be expanded by other studies in this direction. The diagnosis of right hyperthyroidism responds to a rigorous parsimony in the use of available means whose cost is a real limiting factor for the subject.


Keywords: Assessment, Hyperthyroidism, Diagnosis, Surveillance
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How to cite this article:

Djiby Sow, Amadou Ndiaye, Boubacar Ndong, Moussa Badiane, Pr Oumar Ndoye and Pr Niama Diop Sall. 2018. Hormonal Balance of Hyperthyroidism in the Laboratory of Biophysics of Dakar: Proposal of a Diagnostic and Monitoring Approach.Int.J.Curr.Microbiol.App.Sci. 7(1): 3466-3472. doi: https://doi.org/10.20546/ijcmas.2018.701.408