International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:6, June, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(6): 908-915

Immunoglobulin E, Interleukin-17A and Transforming Growth Factor-β1 Levels in Children with Nephrotic Syndrome
Ahmed Abdul-hassan Abbas1, Yasmin Sahib Mahdi2 and Shatha Hussain Ali3*
1Department of Microbiology, College of Medicine, Al-Nahrain University, Iraq
2Department of pediatrics, College of Medicine, Al-Nahrain University- Iraq
3Department of Pediatrics, College of Medicine, Al-Nahrain University,P.O. Box 70074, Baghdad-Iraq
*Corresponding author

The etiology of Nephrotic syndrome (NS) is unknown however various evidences suggest that immune dysfunction play a key role in the pathogenesis of NS. This study was established to investigate the role of IgE in the pathogenesis of NS, and some immune mediators (IL-17A and TGF-β1). Fifty three patients with NS  were enrolled in the present study, aged from 2 to 17 years.  Control group consist of 27 healthy children. Blood samples were collected from patients and controls to assess serum levels of IgE, IL-17A and TGF-β1 by Enzyme-Linked Immunosorbant Assay (ELISA). The level of both IgE and IL-17A was significantly higher in NS patients than healthy control, and the level was higher in patients with resistant to steroid than sensitive and in relapse phase than in remission phase and in patients with history of allergy than those patients without history of allergy. Whereas the level of TGF-β1 was lower in NS patients as compared with control and lower in patients with relapse phase and newly diagnosed than in patients with remission phase and lower in steroid resistant patients than steroid sensitive patients .While the level of TGF-β1 was higher in patients with history than those without history of allergy. Patients with NS exhibit increased serum level of IgE and this may be related to sensitivity to steroid treatment. Moreover, IL-17A/TGF-β1ratio imbalance may act as a potential factor in the pathogenesis of NS.

Keywords: Nephrotic syndrome,IgE,IL-17A,TGF-β1,Children.

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How to cite this article:

Ahmed Abdul-hassan Abbas, Yasmin Sahib Mahdi and Shatha Hussain Ali. 2013. Immunoglobulin E, Interleukin-17A and Transforming Growth Factor-β1 Levels in Children with Nephrotic Syndrome.Int.J.Curr.Microbiol.App.Sci. 5(6): 908-915. doi:
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