International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:6, June, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(6): 837-855

A Review on Efflux Pump Inhibitors of Gram-Positive and Gram-Negative Bacteria from Plant Sources
Rakesh Kumar* and Savita Jandaik Pooja Patial
Department of microbiology, Shoolini university of Biotechnology and Management Sciences, Solan, Himachal Pradesh, India  Pin- 173212
*Corresponding author

Resistance of bacteria to most of the classes of antibiotics is a big problem now days. The component responsible for resistance in both the gram positive and gram negative bacteria are classified as multidrug resistant efflux pumps.  In recent years a huge number of efflux pumps are identified in both gram- positive and gram- negative bacteria and these efflux pumps are responsible for the intrinsic resistance of bacteria to most of the antibiotics. Efflux pump inhibitors are the compounds which inhibit the activity of efflux pumps and they have the potential to restore the activity of standard antibiotics. In recent years, there are many classes of efflux pump inhibitors has been reported. Some of these efflux pump inhibitors are synthetic while some of them are natural inhibitors. Efflux pump inhibitors derived from chemical sources have drawbacks as they shows toxic effect at high concentrations in which they can be used. Some plants show potential EPI activity along with some antibiotics and shows effect on many efflux pumps. This review focuses on the use of efflux pump inhibitors from natural sources for blocking the activity of efflux pumps in case of both gram positive and gram negative bacteria.

Keywords: EPI,Efflux pumps, Gram-Positive and Gram-Negative Bacteria Bacteria

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How to cite this article:

Rakesh Kumar and Savita Jandaik Pooja Patial. 2016. A Review on Efflux Pump Inhibitors of Gram-Positive and Gram-Negative Bacteria from Plant Sources.Int.J.Curr.Microbiol.App.Sci. 5(6): 837-855. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.