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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(6): 798-805
DOI: http://dx.doi.org/10.20546/ijcmas.2016.506.089


Secular Trend of Antibiotic Resistance in Blood Stream Infections-A retrospective Analysis
Shweta Bohra*, Anamika Vyas, Mrityunjay Kumar and A. S. Dalal
Department of Microbiology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
*Corresponding author
Abstract:

Bloodstream infections (BSIs) are among the most serious infections acquired by hospitalized patients requiring intensive care. The existence of a pathogen population with an ever-increasing resistance to antibiotics has complicated the clinical problems. This retrospective study was undertaken with a view to compile and analyse the common isolates of BSIs along with resistance pattern in a tertiary care teaching hospital. Retrospective study was conducted to identify the microbial profile in the blood culture isolates and their antibiotic susceptibility patterns in a tertiary care teaching hospital. The reports of specimens submitted for blood culture during the period of 2012-2015 to the microbiology laboratory were obtained, the positive cultures were identified, and data on the microbial species and their antibiotic patterns were collected and statically analysed. There were 4964 blood culture samples, of which 543were identified to be culture positive. Of the total culture positives177 (32.59%) were Gram positive bacteria; 309 (56.91%) were gram negative bacteria and 57 (10.50%) were Candida species. Among the gram positive bacteria150 (27.62%) were Coagulase negative Staphylococci (CoNS); 16 (2.94%) were Staphylocococcus aureus and 11 (2.02%) were Enterococcus species. In the Gram negative bacteria E.coli was 140 (25.78%); Klebsiella pneumonia was 92 (16.94%); Acinetobacter species was 25 (4.60%); Pseudomonas specieswas32 (5.89%). Statically significant resistance was observed in CoNS for Oxacillin; in E.coli for Ciproflaxacin, Amoxicillin-clavulanic acid, Piperacillin + tazobactam, Cefuroxime; and in Klebsiella pneumoniae for Amoxicillin-clavulanic acid, Piperacillin+tazobactam, Imipenem. CoNS is the common gram positive isolates followed by E.coli and Klebsiella pneumoniae in gram negative organisms of BSI in our setup. Significant resistance was observed for third generation cephalosporins, fluoroquinoles and piperacillin +tazobactam combination. Ongoing surveillance for antimicrobial susceptibility remains essential in case of BSI and will enhance efforts to identify resistance and attempt to prevent its spread.


Keywords: Blood Stream Infections (BSIs),Antibiotic Resistance,CoNS.
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How to cite this article:

Shweta Bohra, Anamika Vyas, Mrityunjay Kumar and A.S. Dalal. 2016. Secular Trend of Antibiotic Resistance in Blood Stream Infections-A retrospective Analysis.Int.J.Curr.Microbiol.App.Sci. 5(6): 798-805. doi: http://dx.doi.org/10.20546/ijcmas.2016.506.089