International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:6, June, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(6): 511-521

Study of Bacterial Profile in Neonatal Sepsis and their Antibiotic Sensitivity Pattern in a Tertiary Care Hospital
K.V.Leela1, R.Narayana Babu2, Sugunya2, Venkata Madhu Prasad3
 and Ramisetty Raaga Deepa1
1Department of Microbiology, Govt. Kilpauk, Medical College and Hospital, Chennai, India
2Department of Pediatrics, Govt. Kilpauk, Medical College and Hospital, Chennai, India
3Academic officer, Govt. Kilpauk Medical College and Hospital, Chennai, India
*Corresponding author

Septicemia remains a significant cause of morbidity and mortality in the new-borns. The main objective of the study was to identify the common bacterial pathogens associated with neonatal sepsis and their antibiotic sensitivity pattern. During July 2015 and August 2015, 232 Blood samples were collected aseptically from newborns with sepsis in Govt. Kilpauk Medical College, Chennai and processed by standard conventional method. Antibiotic susceptibility pattern of isolates was studied by Kirby Bauer Disc diffusion technique as per the CLSI recommendations. 83 out of 232 cases were culture positive, giving a culture positivity rate of around 35.77%. Males were more affected than their female counterparts. 85.5% of cases are reported in the early days of life and Gram negative bacilli were found to be the commonest cause of neonatal septicemia (56.5%). Klebsiella pneumonia (39.75%) was the most frequent isolate which showed 90.9% sensitivity against Amikacin. All the Gram negative bacilli were found to be highly sensitive to third generation cephalosporins especially Cefperazone sulbactum . All the gram positive isolates showed 100% sensitivity to Vancomycin. The study concludes that it is important to continue the tracking of neonatal septicemia in order to closely monitor the changes in trends, to obtain information for empiric antibiotic therapy and to act rapidly in case of emergencies. Since Govt. Kilpauk Medical College being a tertiary health care centre, most of its sepsis cases are referred ones. Hence awareness should be created about institutional deliveries along with antenatal and postnatal care.

Keywords: Neonatal sepsis, Multidrug resistance, Septicemia.

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How to cite this article:

Leela, K.V., R. Narayana Babu, Sugunya, Venkata Madhu Prasad  and Ramisetty Raaga Deepa. 2016. Study of Bacterial Profile in Neonatal Sepsis and their Antibiotic Sensitivity Pattern in a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 5(6): 511-521. doi:
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