International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:6, June, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(6): 338-344

Can a Duplex Non-treponemal and Treponemal Serological Test Help in Improving Syphilis Testing
Mayur R. Shukla*
Department of Microbiology, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan-333001, India
*Corresponding author

Treponemal and non-treponemal serological tests are the most commonly used for syphilis diagnosis. The traditional syphilis testing algorithm recommends the screening of samples with a non-treponemal test. Whereas, the reverse and European Centers for Disease Control (ECDC) testing algorithms advocate the use of a treponemal test for syphilis screening. The popularity of treponemal tests has recently gained interest due to their availability in the automated test format. In contrast to that, non-treponemal tests are not available in such format. Though, their usefulness cannot be underestimated. They are very helpful in determining active syphilis infection, and monitoring the progress of treatment. Hence, combing both different tests on a single platform can be very useful to those laboratories that are engaged with huge number of sample testing. Such test could possibly be designed in a duplex chemiluminescent immunoassay (CLIA) system. It can aid in improving routine syphilis screening with the advantage of fast testing, better result interpretation, and a potential for automation. In addition to that, it can satisfy the requirements of described testing algorithms. However, this duplex test needs to have sensitivity, and specificity equivalent to currently used serological tests for advancing its further use in syphilis diagnosis.

Keywords: Syphilis, Treponemal test, Non-treponemal test, CLIA, ECDC.

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How to cite this article:

Mayur R. Shukla. 2016. Can a Duplex Non-treponemal and Treponemal Serological Test Help in Improving Syphilis Testing?Int.J.Curr.Microbiol.App.Sci. 5(6): 338-344. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.