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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(11): 3377-3395
DOI: https://doi.org/10.20546/ijcmas.2017.611.397


Antimicrobial Efficacy of Cinnamonum verum Essential Oil Alone and in Combination with Antibiotics and Other Essential Oils
Hemali Padalia, Tejas Rathod, Pooja Moteriya and Sumitra Chanda*
Phytochemical, Pharmacological and Microbiological Laboratory, Department of Biosciences (UGC-CAS), Saurashtra University, Rajkot, 360 005, Gujarat, India
*Corresponding author
Abstract:

Microbial resistance to antibiotics is a global health problem. Infectious diseases are increasing day by day for various untackable reasons. Thus, there is an urgent need to develop novel antimicrobial agents from natural substances such as plants which are easily available with no toxic effects which are generally associated with synthetic drugs. Besides there is every chance of getting a new drug or lead to drug molecule because of the vast diversity which they possess. The present study was designed to examine synergistic antimicrobial activity of Cinnamon (Cinnamonum verum) oil with some commercial antibiotics and some other essential oils against a panel of multidrug resistant microorganisms. The composition of Cinnamon oil was characterized by GC-MS analysis, the principal compound identified was cinnamaldehyde (62.28%) and benzyl alcohol (24.60%). Combination of Cinnamon oil with antibiotics and other essential oils showed synergistic antimicrobial activity by disc diffusion method. Microbes which showed significant sensitivity were further assayed with various concentrations of the potent combination of Cinnamon oil in a broth dilution method and determined by fractional inhibitory concentration (∑FIC) index. Among the different combinations, Cinnamon oil with ampicillin and Cinnamon oil with Clove oil was found to be most effective combination against pathogenic microorganisms. Synergistic potential of Cinnamon oil can be a new and important way for the treatment of infectious diseases.


Keywords: Cinnamonum verum, Essential oil, Antibiotics, Synergistic antimicrobial activity.
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How to cite this article:

Hemali Padalia, Tejas Rathod, Pooja Moteriya and Sumitra Chanda. 2017. Antimicrobial Efficacy of Cinnamonum verum Essential Oil Alone and in Combination with Antibiotics and Other Essential Oils.Int.J.Curr.Microbiol.App.Sci. 6(11): 3377-3395. doi: https://doi.org/10.20546/ijcmas.2017.611.397