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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(1): 522-527
DOI: http://dx.doi.org/10.20546/ijcmas.2016.501.052


Circadian Variation in Oxidative Stress Markers in Alcoholic Hepatitis Patients
Sanjay Bhatt, Maliyannar Itagappa, Bindu Sati, J.B.Gogoi, Monika Pathaniya, Rana Shinde, and Jyoti Batra
Department of Biochemistry, R.M.R.I, Bareilly, India
Department of Medicine, V.C.S.G.G.I.M.S and R Srinagar Garhwal, India
Department of Biochemistry, Santosh Medical College and Hospital, Ghaziyabad, India
*Corresponding author
Abstract:

The circadian periodicity of plasma lipid peroxide levels and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), glutathione reductase (GSH), total antioxidant status were studied in 30 clinically, alcoholic hepatitis proven fresh cases (age: 18-70 years) and 30 age matched healthy volunteers with diurnal activity from 06:00 to about 22:00 and nocturnal rest. A marked circadian variation in plasma lipid peroxide level was recorded in healthy subjects and alcoholic patients with significant amplitude and acrophase around 16:21 and 17:12 respectively. The acrophase tended to be delayed in alcoholic patients. Furthermore, a statistically significant circadian rhythm was found in SOD, CAT and GPx, GSH, TAS, MDA activities in normal volunteers and alcoholic hepatitis patients. SOD and CAT enzyme activity was noted to be maximum at 06:00 and minimum at 00:00 in alcoholic hepatitis patients. The circadian acrophase for GPx activity was recorded at 16:15 in normals and around 22:45 in patients. Moreover, the activity was found to be decreased at all sampling hours during 24-hours sleep-awake period in patients in comparison to healthy counterparts. The MESOR and circadian amplitude also decreased markedly. The decreased activity of measured antioxidant enzymes in Alcoholic hepatitis patients could probably be associated with oxidative stress and/or decreased anti-oxidant defensive mechanism in such patients.


Keywords: Circadian Variation, Oxidative Stress Markers, Alcoholic Hepatitis
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How to cite this article:

Int.J.Curr.Microbiol.App.Sci. 5(1): 522-527. doi: http://dx.doi.org/10.20546/ijcmas.2016.501.052