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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(5): 788-795
DOI: http://dx.doi.org/10.20546/ijcmas.2016.505.079


Effect of Anabolic Steroid in Accelerating Healing Process of Experimentally Fractured Tibia of Rats and Compare its
Fracture Healing Property with Terminalia  arjuna
Giri Reena1*, Giri Kiran2 and Palandurkar Kamlesh3
1Department of Pharmacology, GMC, Medical College, Rajnandgaon, CG, India
2Department of Pharmacology, BHU, India
3Department of Biochemistry, BHU, India
*Corresponding author
Abstract:

Musculoskeletal injuries existed throughout human history.“Fracture” defined as a break in the continuity of the bone. Prolonged period required for healing of fractures  entails much suffering & economic loss to the  patient. Varied products from vitamins to hormones - tried to hasten the process of bone healing - unfortunately without positive outcome. Arjun tree with its roots in Indian mythology, known to have good effects on bone healing from many centuries. Anabolic steroids, are a class of steroid hormones related to the hormone testosterone. They increases protein synthesis within cells, which results in the building up of cellular tissue. Except few studies, no extensive investigations have been made for improving this inherent biological phenomenon of bone healing. Hence, the research question was formulated as “whether the herb Arjuna terminalia & anabolic steroid induce favorable response in bone healing & to evaluate their fracture healing property radiologically. In our study we induce fracture in 16 wistar albino rats of either sex using 3-point bending method. Two treatment groups made as Terminalia arjuna & anabolic steroid group. Treatment given for 4 weeks & rats investigated radiologically for fracture healing phenomenon. Terminalia arjuna treated animals revealed faster initiation of healing process than anabolic steroid treated group. Healing was almost complete within four weeks of fracture in Terminalia arjuna treated animals & remained incomplete in anabolic steroid treated animals. Our study indicates - daily administration of an alcoholic extract of Arjuna terminalia orally in the dosage of 500mg/kg has definite action on the rate of healing of fractures.


Keywords: 3-point bending,radiological examination
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How to cite this article:

Giri Reena, Giri Kiran and Palandurkar Kamlesh. 2016. Effect of Anabolic Steroid in Accelerating Healing Process of Experimentally Fractured Tibia of Rats and Compare its Fracture Healing Property with Terminalia  arjuna.Int.J.Curr.Microbiol.App.Sci. 5(5): 788-795. doi: http://dx.doi.org/10.20546/ijcmas.2016.505.079